New radiation tile could change brain metastasis treatment

NCT ID NCT04365374

Ongoing Disease control Sponsor: GT Medical Technologies, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests a new radiation device called Gamma Tile, which is placed directly in the brain during surgery to deliver radiation immediately, versus standard radiation given weeks later. The study involves 230 adults with newly diagnosed brain metastases who need one tumor removed. The goal is to see if Gamma Tile improves tumor control and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gamma Tile (a permanently implanted radiation device with cesium-131 seeds)
What this could lead to: If successful, this could offer a more convenient and potentially more effective radiation option for people with brain metastases, reducing the need for follow-up radiation sessions.
What could go wrong: This is a phase 3 trial, but results are not yet available. The Gamma Tile is a new device, and long-term safety or effectiveness compared to standard care is still unproven. Risks include infection, radiation side effects, or the device not improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

Locations

Abbott Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Advent health Orlando

Orlando, Florida, 32804, United States
Albany Medical Center

Albany, New York, 12208, United States
Allegheny Health Network

Pittsburgh, Pennsylvania, 15212, United States
Ascension St. Vincent's- Riverside

Jacksonville, Florida, 32204, United States
Baptist MD Anderson Cancer Center- Jacksonville

Jacksonville, Florida, 32207, United States
Baylor St. Luke's Medical Center | Baylor College of Medicine

Houston, Texas, 77030, United States
Brown University Health

Providence, Rhode Island, 02906, United States
Dartmouth-Hitchcock

Lebanon, New Hampshire, 03766, United States
ECU Health

Greenville, North Carolina, 27834, United States
Ellis Fischel Cancer Center at University of Missouri

Columbia, Missouri, 65212, United States
Florida Health Sciences Center, Inc. d/b/a Tampa General Hospital

Tampa, Florida, 33606, United States
HCA Florida First Coast Neurology- Orange Park

Orange Park, Florida, 32073, United States
HMH Jersey Shore University Medical Center

Neptune City, New Jersey, 07753, United States
Henry Ford Health

Detroit, Michigan, 48202, United States
HonorHeath Scottsdale Osborn Medical Center

Phoenix, Arizona, 85027, United States
Houston Methodist

Houston, Texas, 77030, United States
Indiana University, IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States
Mayfield Brain and Spine

Cincinnati, Ohio, 45209, United States
Memorial Sloan Kettering

New York, New York, 10065, United States
Orlando Health

Orlando, Florida, 32806, United States
Piedmont Hospital

Atlanta, Georgia, 30309, United States
RUSH University

Chicago, Illinois, 60607, United States
SCRI with Texas Oncology

The Woodlands, Texas, 77380, United States
SSM Health Saint Louis University Hospital

St Louis, Missouri, 63110, United States
The University Of Kansas Cancer Center

Kansas City, Kansas, 66016, United States
The University of Texas M. D. Anderson Cancer Center

Houston, Texas, 77030, United States
UT Health San Antonio

San Antonio, Texas, 78249, United States
UT Southwestern Simmons Cancer Center

Dallas, Texas, 75235, United States
University Of Minnesota

Minneapolis, Minnesota, 55414, United States
University of Arkansas Medical Center

Little Rock, Arkansas, 72205, United States
University of Louisville

Louisville, Kentucky, 40202, United States
University of North Carolina Health

Chapel Hill, North Carolina, 27599, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Virginia Mason

Seattle, Washington, 98101, United States
Westchester Medical Center

Westchester, New York, 10595, United States
Winship Cancer Institute of Emory University

Atlanta, Georgia, 30322, United States

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