BRAIN METASTASES

This early-phase study tested whether giving a type of focused radiation (stereotactic radiosurgery) after the immunotherapy drug nivolumab is safe and effective for people with breast cancer that has spread to the brain. Fourteen participants were enrolled to check for serious s…

This study tested a drug called furmonertinib in 24 adults with advanced lung cancer (non-small cell) that has specific EGFR gene changes and has spread to the brain. The goal was to see if the drug can control brain tumors and delay their growth. Participants took the drug and w…

This study tested a new drug, AZD3759, against standard treatments for people with advanced lung cancer that has spread to the brain. The drug is designed to better reach and attack cancer cells in the brain. The trial involved 492 adults and found that AZD3759 helped keep the ca…

This study tested giving a precise, high-dose radiation treatment (stereotactic radiosurgery) before surgically removing large brain metastases in 30 patients. The goal was to see if this approach lowers the risk of serious side effects and helps control the tumor locally. Partic…

This small pilot study tested a new order of treatment for people with brain metastases (cancer that spread to the brain). Instead of the usual surgery first, patients received focused radiation (gamma knife) before surgery. The goal was to see if this approach could better contr…

This study tested a new way to treat breast cancer that has spread to the brain. Doctors used sound waves guided by MRI to temporarily open the brain's protective barrier, allowing cancer drugs to reach the tumors. The study included 8 people with a specific type of breast cancer…

This study tested giving a precise, high-dose radiation treatment before surgery to remove brain metastases in 70 adults with cancer. The goal was to see if this approach could better control tumor regrowth at 6 months and reduce long-term side effects like radiation necrosis. Pa…

This study tested a new MRI contrast agent called RVP-001, which does not contain gadolinium, in 18 adults with brain lesions from conditions like tumors or multiple sclerosis. The goal was to see if it is safe and effective at highlighting these lesions compared to standard gado…

This study tested whether a special PET scan called DOPA PET/CT can find untreated brain metastases (cancer that spread to the brain) as well as or better than standard MRI. Researchers studied 32 adults with lung cancer, breast cancer, or melanoma who had at least one brain meta…

This study tested whether a special type of PET scan (F-DOPA) taken very soon after injection can help doctors tell the difference between a brain tumor coming back and damage from radiation therapy. Eight adults with brain metastases who were already scheduled for this PET scan …

This study tested a special counseling program called CALM (Managing Cancer and Living Meaningfully) for people with brain cancer. 60 participants were split into two groups: one received CALM plus usual care, the other just usual care. The goal was to see if CALM is practical an…

This study tested higher doses of a precise type of radiation (stereotactic radiotherapy) given over five sessions for people with brain metastases that are 2 to 6 centimeters in size. The goal was to find the highest safe dose and to track any side effects. Thirteen adults with …

This study gathered information from 968 people with brain tumors who received a special type of radiation treatment called HyperArc. The goal was to see how well this treatment works and how it compares to other options. The study did not test a new drug or cure, but rather coll…

This study looked at the genetic and epigenetic changes in brain metastases (cancers that spread to the brain from other parts of the body). Researchers compared these changes in tumor tissue and liquid biopsies (blood and spinal fluid) from 21 adult patients. The goal was to bet…