BRAIN METASTASES

This study tested if a new drug, AZD3759, could control advanced lung cancer that had spread to the brain better than standard drugs. It involved nearly 500 adults with a specific genetic mutation (EGFR+) who had not yet received treatment for their advanced cancer. The main goal…

This study tested whether giving targeted radiation before surgery helps control large brain tumors that have spread from other cancers. Thirty patients with 1-6 brain tumors, where at least one needed surgical removal, received precise radiation treatment first, followed by surg…

This study tested an oral drug called furmonertinib in patients with advanced non-small cell lung cancer (NSCLC) that had spread to the brain. The goal was to see how well the drug controlled the cancer in the brain and body, and how safe it was. It specifically enrolled 24 patie…

This early-phase study tested whether combining a precise form of radiation (stereotactic radiosurgery) with an immunotherapy drug (nivolumab) is safe and can help control breast cancer that has spread to the brain. It involved 14 adults with metastatic breast cancer and brain tu…

This small study tested whether using focused ultrasound to temporarily open the blood-brain barrier is safe and possible. The barrier normally protects the brain but can block cancer drugs. Eight patients with breast cancer that had spread to the brain received the ultrasound tr…

This small pilot study tested a new order of treatment for patients with 1 to 4 brain tumors that have spread from other cancers. Instead of the usual surgery followed by radiation, researchers gave a precise, high-dose radiation treatment first, then performed surgery within 10 …

This study tested whether giving higher doses of a specialized, targeted radiation treatment over five sessions was safe and effective for patients with larger brain tumors that spread from other cancers. It involved 13 patients with brain metastases to find the maximum dose the …

This study collected information on a new, streamlined radiation technique called HyperArc, used to treat brain tumors and cancer that has spread to the brain. It aimed to see how well this method works and how it compares to other treatments. The registry included nearly 1,000 a…

This study tested whether giving precise, high-dose radiation before surgery helps control brain metastases better. It involved 70 adults with 1-4 brain tumors from breast, lung, or digestive cancers who were eligible for both surgery and radiation. Researchers measured whether t…

This study tested a new type of PET scan to help doctors tell the difference between brain cancer that has returned and damage caused by previous radiation treatment. It involved 8 adults with brain metastases who were already scheduled for a specific PET scan as part of their ca…

This study tested a new MRI contrast agent called RVP-001, which uses manganese instead of gadolinium, to see if it could safely and effectively detect lesions in the brain and central nervous system. It involved 18 adults with known conditions like brain tumors or multiple scler…

This study tested a special therapy program designed to help people with advanced brain cancer manage the emotional distress that comes with their diagnosis. Researchers compared the therapy, called CALM, to standard care in 60 patients. The main goal was to see if the program wa…

This study aimed to understand the molecular changes that occur when cancer spreads to the brain. Researchers compared tissue from surgically removed brain tumors with blood and spinal fluid samples from 21 patients. The goal was to see if less invasive tests could reveal the sam…