Can more radiation sessions tame large brain tumors safely?

NCT ID NCT03412812

Completed Disease control Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving higher doses of radiation over five sessions is safe for people with brain metastases that are 2 to 6 cm in size. These larger tumors are often too risky for a single high-dose treatment. The trial enrolled 13 adults and aimed to find the highest dose that does not cause severe side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy
What this could lead to: If successful, this could establish a safer, more effective radiation dose for treating larger brain tumors that are not good candidates for single-session radiosurgery.
What could go wrong: This is a very early, small (13 participants) dose-finding study, not a large efficacy trial. The results may not apply to all patients, and there is a risk of radiation-related brain swelling or other toxicity.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

Locations

Hazelrig-Salter Radiation Oncology Center

Birmingham, Alabama, 35233, United States

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