New pill shows promise against lung cancer brain metastases

NCT ID NCT03653546

Completed Disease control Sponsor: Alpha Biopharma (Jiangsu) Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a new drug called AZD3759 against standard targeted therapies (erlotinib or gefitinib) in 492 people with advanced EGFR-mutant lung cancer that had spread to the brain. The goal was to see if AZD3759, which is designed to better reach the brain, could keep the cancer from growing longer. Results showed that AZD3759 improved progression-free survival compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AZD3759 (a targeted therapy pill that crosses into the brain)
What this could lead to: If it works, this could offer a more effective first-line treatment for people with EGFR-mutant lung cancer that has spread to the brain, potentially delaying disease progression.
What could go wrong: This is a completed Phase II/III trial, but results may not apply to all patients. Side effects and long-term benefits are still being evaluated, and the drug is not yet widely approved.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer lung neoplasm metastatic malignant neoplasm in the brain neoplasm non-small cell lung carcinoma respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES EGFR GENE MUTATION NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

China site

Hefei, Anhui, 230001, China
China site

Chongqing, China, 400037, China
China site

Fuzhou, Fujian, 350014, China
China site

Xiamen, Fujian, 361003, China
China site

Guangzhou, Guangdong, 510080, China
China site

Guangzhou, Guangdong, 510180, China
China site

Haerbin, Heilongjiang, 150081, China
China site

Zhengzhou, Henan, 450008, China
China site

Zhengzhou, Henan, 450052, China
China site

Wuhan, Hubei, 430022, China
China site

Wuhan, Hubei, 430030, China
China site

Wuhan, Hubei, 430079, China
China site

Yichang, Hubei, 443003, China
China site

Changsha, Hunan, 410013, China
China site

Nanjing, Jiangsu, 210002, China
China site

Nanjing, Jiangsu, 210009, China
China site

Suzhou, Jiangsu, 215004, China
China site

Wuxi, Jiangsu, 214062, China
China site

Xuzhou, Jiangsu, 221002, China
China site

Yangzhou, Jiangsu, 225001, China
China site

Changchun, Jilin, 130012, China
China site

Changchun, Jilin, 130021, China
China site

Xi'an, Shaanxi, 710061, China
China site

Linyi, Shandong, 276000, China
China site

Weifang, Shandong, 261000, China
China site

Yantai, Shandong, 264000, China
China site

Chengdu, Sichuan, 610041, China
China site

Kunming, Yunnan, 650118, China
China site

Hangzhou, Zhejiang, 310003, China
China site

Hangzhou, Zhejiang, 310022, China
China site

Hangzhou, Zhejiang, 311100, China
China site

Beijing, 100021, China
China site

Beijing, 100071, China
China site

Beijing, 100142, China
China site

Beijing, 100730, China
China site

Chongqing, 400030, China
China site

Chongqing, 400042, China
China site

Shanghai, 200030, China
China site

Shanghai, 200032, China
China site

Tianjin, 300052, China
China site 0123

Jinan, Shandong, 250117, China
Korea Site

Seoul, 03080, South Korea
Korea Site

Seoul, 06351, South Korea
Korea Site

Taebuk, 28644, South Korea
Korea site

Daegu, 42415, South Korea
Korea site

Gyeonggi-do, 16247, South Korea
Korea site

Gyeongsang, 52727, South Korea
Korea site

Incheon, 21565, South Korea
Korea site

Seoul, 05368, South Korea
Korea site

Seoul, 06591, South Korea
Korea site

Seoul, 07061, South Korea
Korea site

Suwon, 16499, South Korea
Korea site

Ulsan, 44033, South Korea
Singapore site

Singapore, 308433, Singapore
Taiwan site

Taichung, 407, Taiwan
Taiwan site

Tainan, 704, Taiwan
Taiwan site

Taipei, 100, Taiwan
Taiwan site

Taoyuan, 333, Taiwan

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