When is the best time to zap brain tumors? new trial tests before, during, or after surgery

NCT ID NCT05871307

Ongoing Disease control Sponsor: University Hospital Heidelberg Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial looks at the best time to give radiotherapy for brain metastases that can be surgically removed. It compares giving radiation before surgery, during surgery, or after surgery. The goal is to see which timing best prevents the tumor from coming back. About 90 adults with solid tumors that have spread to the brain will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Radiotherapy (stereotactic radiosurgery or intraoperative radiation)
What this could lead to: If successful, this trial could identify the best timing for radiotherapy to improve local tumor control and reduce recurrence after brain metastasis surgery.
What could go wrong: This is a small, early-phase (phase II) exploratory trial with only 90 participants, so results may not be definitive or widely applicable. Different timings carry varying risks of radiation side effects or surgical complications.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES RADIOTHERAPY

Contacts and locations

Locations

Department of Radiotherapy, University of Heidelberg

Heidelberg, 69120, Germany

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