Immunotherapy duo takes on brain tumors in melanoma patients

NCT ID NCT02374242

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether the immunotherapy drug nivolumab, alone or combined with ipilimumab, can shrink melanoma tumors that have spread to the brain. About 76 adults with stage IV melanoma and at least one brain metastasis will receive treatment. The main goal is to see how many patients have their brain tumors shrink or disappear.

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Conditions

The condition(s) this trial relates to.

brain cancer melanoma metastatic malignant neoplasm in the brain metastatic melanoma Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Melanoma Institute Australia

    Wollstonecraft, New South Wales, 2065, Australia

  • Peter MacCallum Cancer Centre

    East Melbourne, Victoria, 3002, Australia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia