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Brain tumor trial combines radiation with targeted drugs and immunotherapy

NCT ID NCT04074096

Ongoing Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding focused radiation (stereotactic radiosurgery) to a combination of targeted drugs (binimetinib and encorafenib) and an immunotherapy (pembrolizumab) can better control melanoma that has spread to the brain. It includes 10 adults with a specific genetic mutation (BRAF V600). The goal is to see if the radiation helps prevent brain tumors from growing back.

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Conditions

The condition(s) this trial relates to.

brain cancer melanoma metastatic malignant neoplasm in the brain metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAF V600 MUTATION BRAIN METASTASES MALIGNANT MELANOMA

Contacts and locations

Locations

  • APHM - Hopital De La Timone

    Marseille, France

  • APHP - Hôpital Ambroise Paré

    Boulogne-Billancourt, France

  • APHP - Hôpital Avicenne

    Bobigny, France

  • APHP - Hôpital Henri Mondor

    Créteil, France

  • APHP - L'hôpital de la Pitié-Salpêtrière

    Paris, France

  • CHU De Montpellier - Hopital Saint Eloi

    Montpellier, France

  • CHU Nice - Hôpital de l'Archet

    Nice, France

  • CHU de Bordeaux - Hôpital Saint André

    Bordeaux, France

  • CHU de Caen

    Caen, France

  • CHU de Dijon - Hopital Du Bocage

    Dijon, France

  • CHU de Nantes - Hôtel Dieu

    Saint-Herblain, France

  • CHU de TOURS - Hôpital Bretonneau

    Tours, France

  • CLCC - Centre Antoine Lacassagne

    Nice, France

  • CLCC - Centre Georges François Leclerc

    Dijon, France

  • CLCC - Centre Jean François Baclesse

    Caen, France

  • CLCC - Centre Léon Bérard

    Lyon, France

  • CLCC - Gustave Roussy

    Villejuif, France

  • CLCC - IUCT-0 / Institut Claudius Regaud

    Toulouse, France

  • CLCC - Institut de Cancerologie de Montpellier

    Montpellier, France

  • CLCC - Institut de Cancerologie de l'Ouest - Nantes

    Saint-Herblain, France

  • GH Sud CHU Bordeaux - Hôpital Levêque

    Bordeaux, France

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