MALIGNANT MELANOMA

This study tests an experimental drug called AMT-253 in people with advanced melanoma or other solid tumors that have spread or cannot be removed by surgery. Participants must have already tried at least one standard treatment without success. The goal is to see if the drug can s…

This study tests a new drug called CTX-8371 in people with advanced cancers that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. About 85 adults with certain types of lung, breast, lymphoma, head and neck, or skin can…

This study tests a new drug called TCC1727 combined with other cancer treatments (benmelstobart, olaparib, or topotecan) for people with advanced solid tumors that have stopped responding to standard therapy. The goal is to find the safest dose and see if the combination can shri…

This study tests whether adding a personalized mRNA vaccine (V940) to standard immunotherapy (pembrolizumab) can stop advanced melanoma from growing or spreading. About 160 people with stage III or IV melanoma that cannot be removed by surgery will receive either the vaccine plus…

This early-phase study tests a new experimental drug (LB-LR1109) in people with advanced solid tumors like lung, kidney, or skin cancer that no longer respond to standard treatments. The study has two parts: first, the drug is given alone to find the safest dose; second, it is co…

This study tests a vaccine made from modified melanoma cells to help the immune system recognize and attack any remaining cancer in patients at high risk of recurrence. It is for people who have had melanoma removed and are now cancer-free or have very little disease left. The go…

This early-phase study tests a new drug called CBA-1205, an antibody that targets a protein (DLK1) found on some cancer cells. The main goal is to check safety and find the right dose in about 66 adults with advanced solid tumors, including liver cancer and melanoma. Participants…

This study tests whether fecal microbiota transplantation (FMT) capsules can help people with diarrhea and colitis caused by immune checkpoint inhibitors, a common side effect of cancer treatment. Twenty adults with melanoma or kidney cancer will receive either FMT or placebo cap…

This study looks at whether a 12-week supervised exercise program can reduce fatigue in adults with advanced melanoma who are receiving immunotherapy or targeted therapy. About 104 participants will be randomly assigned to either an exercise group (online and in-person sessions) …