Brain tumor patients may skip routine steroids during surgery

NCT ID NCT07044557

Recruiting now Symptom relief Sponsor: University of Louisville Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether it is safe to avoid giving the steroid dexamethasone before, during, and for three weeks after brain metastasis surgery. The goal is to see if patients can avoid the side effects of steroids without needing extra rescue doses. The trial will enroll 35 adults with newly found brain tumors and a suspected or confirmed cancer elsewhere in the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: withholding dexamethasone (steroid)
What this could lead to: If successful, this could show that many patients with brain metastases can safely avoid routine steroids around surgery, reducing side effects.
What could go wrong: This is a very small, early-phase study (35 people) with no control group. It only tests whether steroids can be withheld, not whether this improves long-term outcomes. Some patients may still need rescue steroids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

Locations

University of Louisville Hospital
RECRUITING

Louisville, Kentucky, 40202, United States

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