University Of Louisville

This early-stage study tests whether adding a procedure called irreversible electroporation (IRE) to standard chemotherapy can help control locally advanced pancreatic cancer. IRE uses short electric pulses to destroy cancer cells without harming nearby tissues. About 20 adults w…

This study tests a new way to treat advanced pancreatic cancer by combining a drug called Nivolumab (which helps the immune system fight cancer) with a procedure called irreversible electroporation (which uses electric pulses to destroy tumor cells). The goal is to see if this co…

This study tests whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) for 6 months can help people with alcohol use disorder drink less and reduce liver injury. About 60 heavy drinkers with alcohol-related liver disease will receive either LGG or a placebo. The goal…

This study tests whether a combination of electrical spinal cord stimulation and breathing exercises can improve respiratory function in people with chronic spinal cord injury. Researchers will enroll 30 adults with neck-level injuries to measure changes in breathing strength and…

This study looks at whether people with brain metastases can safely avoid taking dexamethasone (a steroid) before and after surgery. Researchers want to see if skipping the drug reduces the need for it later and helps the immune system. The trial involves 35 adults with new brain…

This study tests a non-invasive device that stimulates the spinal cord through the skin to improve walking and balance in people with Parkinson's disease. The treatment targets movement problems that don't respond well to standard medications. Twenty adults with Parkinson's will …

This study tests a program called TIPPI-R that teaches children with cancer and their families simple ways to cope with pain and distress during treatment. About 100 children aged 0-18 and their families will either receive the program or standard care. Researchers will check if …

This study tests whether combining non-invasive spinal cord stimulation with breathing exercises can improve lung function in 36 adults with chronic spinal cord injury. Participants will be split into three groups: breathing training alone, stimulation alone, or both together. Th…

This study is a long-term database that follows 3000 people with gastroparesis, a condition where the stomach empties slowly. Researchers track symptoms, treatments, and quality of life over time to learn more about the disease. No new treatment is given; the goal is to gather in…

This study looks at a new way to treat severe brain bleeds caused by aneurysms. Instead of coiling the whole aneurysm, doctors will only coil the dome (the bulging part). The goal is to see if this lowers the chance of another bleed. About 30 adults with severe bleeds will take p…

This study looks at how people judge distances and heights of objects around them while walking. Researchers want to understand how our vision works during everyday movements like walking or driving. Healthy adults with normal vision will be asked to estimate distances before and…

This study looks at how the environment around you, especially green spaces like parks and trees, may impact your heart health and overall well-being. Researchers will follow 835 adults aged 30-70 living in specific Louisville neighborhoods. They will measure changes in artery st…

This study aims to collect normal measurements from the esophagus and stomach in 40 healthy adults aged 18-85. Participants will undergo quick, FDA-approved balloon tests during an upper endoscopy to measure muscle function and tissue health. The data will help doctors better dia…

This study aims to create a personalized treatment for eating disorders by using mobile technology to track individual symptoms and social factors. Researchers will first study 900 people to understand their unique needs, then test a tailored treatment in 240 participants against…

This study tests whether using sterile water instead of Betadine to clean the urethra before placing a temporary catheter changes the chance of getting a urinary tract infection or causes more pain. About 148 adults who need a catheter in the clinic will take part. The goal is to…