New combo therapy targets brain metastases in lung cancer patients

NCT ID NCT06248606

Recruiting now Disease control Sponsor: Ryan Gentzler, MD Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 21 times

Summary

This study tests whether combining a targeted drug (adagrasib) with precise radiation (SRS) can better control brain tumors in people with a specific type of lung cancer (KRAS G12C mutation). About 30 adults with untreated brain metastases will receive both treatments. The goal is to see if the combination improves tumor control in the brain and is safe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••

Contact
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

KRAS G12C NON SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER NSCLC