New combo tackles lung cancer brain tumors without surgery

NCT ID NCT06248606

Recruiting now Disease control Sponsor: Ryan Gentzler, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining a targeted pill (adagrasib) with precise radiation (SRS) can control brain tumors in people with a specific type of advanced lung cancer (KRAS G12C mutation). About 30 adults with untreated brain metastases will receive both treatments. The main goal is to see how many patients' brain tumors shrink or stop growing after 3 months.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm in the brain non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KRAS G12C NON-SMALL CELL LUNG CANCER NSCLC

Contacts and locations

Locations

Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
University of Virginia Health System
RECRUITING

Charlottesville, Virginia, 22908, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

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