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Engineered t cells take on brain tumors in first human test

NCT ID NCT07569263

Not yet recruiting Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tests a new type of immunotherapy for adults with brain metastases from various cancers. The treatment uses the patient's own immune cells, modified to better target and attack tumor cells. The main goals are to see if the approach is safe and feasible in 12 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
IL-8 receptor modified CD70 CAR T cells
What this could lead to
If successful, this could point toward a new treatment option for brain metastases that are hard to treat with standard therapies.
What could go wrong
This is a very early Phase I trial with only 12 participants, focused on safety. It may not show benefit, and there are risks of serious side effects from the cell therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UF Health

    Gainesville, Florida, 32610, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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