CLL breakthrough: could some patients finally stop daily pills?
NCT ID NCT04419519
First seen Nov 19, 2025 · Last updated May 08, 2026 · Updated 23 times
Summary
This study looks at whether people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have very low levels of cancer cells (called MRD-negative) after taking venetoclax can stop the drug and stay healthy for at least a year. About 81 adults who are already on or about to start venetoclax (alone or with another drug) will be followed to see how long they can remain off treatment without their cancer coming back. The goal is to reduce side effects and medication burden while keeping the disease under control.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Columbia University
New York, New York, 10032, United States
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Memorial Sloan Kettering Basking Ridge (All protocol activities)
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen (All protocol activities)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack (All protocol activities)
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (All protocol activities)
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester (All protocol activities)
Harrison, New York, 10604, United States
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University of Washington
Seattle, Washington, 98109, United States
Conditions
Explore the condition pages connected to this study.