Radiation jolts immune drugs back to life in advanced cancers

NCT ID NCT03693014

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 17 times

Summary

This study tests whether adding a precise, high-dose radiation treatment (SBRT) can restore the effectiveness of immunotherapy drugs in people with metastatic cancers like melanoma, lung, bladder, kidney, or head/neck cancer. About 69 adults whose cancer has started growing again while on immunotherapy will receive SBRT to up to three tumors while continuing their current immunotherapy. The goal is to see if the combination can shrink or control other tumors not directly treated with radiation.

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Contacts and locations

Locations

  • Hartford Healthcare

    Hartford, Connecticut, 06102, United States

  • Lehigh Valley Health Network

    Allentown, Pennsylvania, 18103, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Rockville Centre

    Rockville Centre, New York, 11570, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

Conditions

Explore the condition pages connected to this study.