New combo therapy targets hard-to-treat metastatic cancers

NCT ID NCT05566574

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests the safety of combining the drug RP-3500 with radiation therapy for people whose cancer has spread and who have a specific gene change (ATM mutation). About 49 adults with advanced solid tumors will receive the combination to find the safest dose and see if it helps control the cancer for at least 6 months. The goal is to ease symptoms and slow tumor growth, not to cure the disease.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CANCER SOLID TUMOR

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activites)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center at Suffolk-Commack (All Protocol Activities)

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)

Harrison, New York, 10604, United States

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