New combo therapy targets tough cancers with gene mutation
NCT ID NCT05566574
First seen Nov 12, 2025 · Last updated Apr 28, 2026 · Updated 27 times
Summary
This study tests the safety of a drug called RP-3500 when given with radiation therapy to people whose metastatic solid tumors have a specific gene change (ATM mutation). About 49 adults with advanced cancer that has spread will take part. The goal is to find the best dose that causes few side effects and to see if the combination can control tumor growth for at least 6 months.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Memorial Sloan Kettering Basking Ridge (Limited Protocol Activites)
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center at Suffolk-Commack (All Protocol Activities)
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, 10604, United States
Conditions
Explore the condition pages connected to this study.