Pancreatic surgery infection showdown: which antibiotic wins?

NCT ID NCT03269994

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 30 times

Summary

This study tested two common antibiotics, cefoxitin and piperacillin-tazobactam, to see which one better prevents surgical site infections after a complex pancreatic surgery called pancreatoduodenectomy. About 967 adults having this surgery took part. The goal was to find the most effective antibiotic to reduce infection rates within 30 days after the operation.

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Contacts and locations

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Locations

Baptist Memorial Healthcare

Memphis, Tennessee, 38120, United States
Baylor Scott & White Health

Dallas, Texas, 75246, United States
Brody School of Medicine at East Carolina University

Greenville, North Carolina, 27834, United States
Duke University

Durham, North Carolina, 27713, United States
Emory University School of Medicine

Atlanta, Georgia, 30322, United States
Gundersen Lutheran Medical Foundation

La Crosse, Wisconsin, 54601, United States
Hackensack Meridian Health / Hackensack University Medical Center Cancer Center

Hackensack, New Jersey, 07601, United States
Hamilton Health Sciences Center (Juravinski Hospital)

Hamilton, Ontario, Canada
Indiana University

Indianapolis, Indiana, 46202, United States
Intermountain Healthcare

Murray, Utah, 84107, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memoral Sloan Kettering Westchester (Consent only)

Harrison, New York, 10604, United States
Memorial Sloan Kettering Basking Ridge (Consent only)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (Consent only)

Commack, New York, 11725, United States
Montefiore Health Systems (Montefiore Medical Center)

The Bronx, New York, 10467, United States
Mount Sinai Hospital

New York, New York, 10029, United States
Mount Sinai West

New York, New York, 10029, United States
NorthShore University Health System

Evanston, Illinois, 60201, United States
Northwestern Medicine (Data Collection)

Chicago, Illinois, 60611, United States
Ohio State University

Columbus, Ohio, 43210, United States
Ottawa Hospital

Ottawa, Ontario, K1H 8L6, Canada
Pennsylvania State Hershey

Hershey, Pennsylvania, 17033, United States
Providence Health & Services (Portland Med Ctr)

Portland, Oregon, 97213, United States
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UC Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198-7680, United States
University of Utah

Salt Lake City, Utah, 84112, United States
University of Washington School of Medicine

St Louis, Missouri, 63110, United States
University of Wisconsin

Madison, Wisconsin, 53792, United States

Conditions

Explore the condition pages connected to this study.

PANCREAS CANCER PANCREAS CANCER PANCREATIC CANCER PANCREATIC DISEASES