Could less radiation be enough for HPV throat cancer?
NCT ID NCT06984861
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether giving lower doses of radiation over a shorter time, along with standard chemotherapy, works as well as the usual higher radiation doses for people with HPV-positive throat cancer. About 74 participants will receive chemoradiation with drugs like cisplatin or carboplatin. The goal is to see if the cancer stays under control for at least two years, while possibly reducing side effects from radiation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy (lower dose) combined with chemotherapy (cisplatin, carboplatin, 5-fluorouracil)
- What this could lead to
- If successful, this could lead to a treatment option that uses less radiation for HPV-positive throat cancer, potentially reducing long-term side effects while maintaining effectiveness.
- What could go wrong
- This is a Phase 2 trial with only 74 participants, so results are preliminary. Lower radiation might not control the cancer as well as standard doses, and chemotherapy side effects remain a risk.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITINGBasking Ridge, New Jersey, 07920, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITINGMontvale, New Jersey, 07645, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITINGMiddletown, New Jersey, 07748, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITINGUniondale, New York, 11553, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Suffolk- Commack (Limited Protocol Activities)
RECRUITINGCommack, New York, 11725, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITINGHarrison, New York, 10604, United States
Contact Phone: •••-•••-••••
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