New combo therapy aims to buy more time for bile duct cancer patients

NCT ID NCT04891289

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares standard chemotherapy (gemcitabine and oxaliplatin) alone versus the same drugs plus a liver-directed chemotherapy (HAI FUDR/dexamethasone) in people with bile duct cancer that has spread within the liver but cannot be removed surgically. About 164 adults with untreated disease will take part. The goal is to see if adding the liver-directed treatment delays cancer growth by at least 3 months on average.

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Conditions

The condition(s) this trial relates to.

cholangiocarcinoma intrahepatic cholangiocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRAHEPATIC CHOLANGIOCARCINOMA

Contacts and locations

Locations

Duke University (Data Collection Only)
RECRUITING

Durham, North Carolina, 27710, United States
Erasmus University (Data Collection Only)
RECRUITING

Rotterdam, 3015 GD, Netherlands
Memorial Sloan Kettering Basking Ridge - Limited Protocol Activities
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen - Limited Protocol Activities
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack - Limited Protocol Activities
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth - Limited Protocol Activities
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau - Limited Protocol Activities
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester - Limited Protocol Activities
RECRUITING

Harrison, New York, 10604, United States
National Heart, Lung, and Blood Institute (NIH) (Data Collection Only)
RECRUITING

Bethesda, Maryland, 20824, United States
Washington University (Data Collection Only)
RECRUITING

St Louis, Missouri, 63110, United States

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