Diet and supplements tested to stop blood cancer before it starts
NCT ID NCT05640843
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a plant-based diet or supplements (omega-3 and curcumin) can change gut bacteria in people with MGUS or smoldering multiple myeloma, conditions that can lead to multiple myeloma. Researchers will measure butyrate levels in stool, a sign of healthy gut bacteria. The goal is to find a way to prevent progression to active cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Whole foods plant-based diet, algae omega-3 plus curcumin supplements
- What this could lead to
- If successful, this could point toward a dietary or supplement approach to slow or prevent progression of MGUS or smoldering multiple myeloma to active multiple myeloma.
- What could go wrong
- This is an early, small study (180 participants) looking at a biomarker (butyrate levels) rather than clinical outcomes like disease progression. The diet and supplements may not change gut bacteria enough to affect the disease, and results may not apply to everyone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Emory University (Data Collection Only)
RECRUITINGAtlanta, Georgia, 30322, United States
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Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
RECRUITINGBasking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen (All Protocol Activities)
RECRUITINGMontvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITINGNew York, New York, 10065, United States
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Memorial Sloan Kettering Monmouth (All Protocol Activities)
RECRUITINGMiddletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (All Protocol Activities)
RECRUITINGUniondale, New York, 11553, United States
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Memorial Sloan Kettering Suffolk- Commack (All Protocol Activities)
RECRUITINGCommack, New York, 11725, United States
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Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITINGHarrison, New York, 10604, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a new immunotherapy stop smoldering myeloma before it becomes active cancer?
- Gene clues may unlock new treatments for bone marrow cancer
- New blood test screening targets hidden cancer in black communities
- Gut bacteria drug shows promise against blood disorder
- New antibody shows promise in slowing early myeloma
- Turmeric and black pepper extract shows promise in slowing early cancers