Stem cell transplant or drug combo: which works better for myeloma?

NCT ID NCT01745588

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two ways to treat multiple myeloma that has come back or stopped responding to treatment. All 23 participants first received a combination of clarithromycin, pomalidomide, and dexamethasone. Then, half got a stem cell transplant followed by pomalidomide, while the other half continued the drug combo. The goal was to see which approach better controls the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pomalidomide, clarithromycin, dexamethasone, and autologous stem cell transplant
What this could lead to: If successful, this could help doctors choose the best treatment sequence for relapsed multiple myeloma, potentially improving disease control.
What could go wrong: This is a small, early-phase study with only 23 participants, so results may not apply to everyone. Both treatments have side effects, and the disease may still progress.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Memorial Sloan Kettering Cancer Center

Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center @ Suffolk

Commack, New York, 11725, United States
Memorial Sloan Kettering Cancer Center at Mercy Medical Center

Rockville Centre, New York, 11570, United States
Memorial Sloan Kettering Cancer Center at Phelps Memorial Hospital Center

Sleepy Hollow, New York, 10591, United States
Memorial Sloan Kettering West Harrison

Harrison, New York, 10604, United States
North Shore LIJ

New Hyde Park, New York, 11040, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
SUNY Upstate Medical University

Syracuse, New York, United States
Weill Medical College of Cornell University

New York, New York, United States

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