New drug combo shows promise for Tough-to-Treat endometrial cancer

NCT ID NCT05156268

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial tested whether combining two drugs, pembrolizumab and olaparib, could help people with persistent or recurrent endometrial cancer or carcinosarcoma. The study enrolled 26 participants and looked at how many responded to treatment and what side effects occurred. The goal was to find a more effective option for those whose cancer has come back or not gone away.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pembrolizumab and olaparib
What this could lead to: If this combination works, it could offer a new treatment option for people with persistent or recurrent endometrial cancer that has not responded to standard therapies.
What could go wrong: This is a small, early-phase trial with only 26 participants, so results may not apply to everyone. The drug combination may cause side effects or may not shrink tumors effectively.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinosarcoma of the corpus uteri endometrial carcinoma endometrial endometrioid adenocarcinoma endometrial serous adenocarcinoma endometrial undifferentiated carcinoma uterine carcinosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL CARCINOSARCOMA

Contacts and locations

Locations

Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Suffolk-Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

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