Gene-Guided drug cocktail shows promise for tough gynaecological cancers
NCT ID NCT04065269
First seen Feb 21, 2026 · Last updated May 13, 2026 · Updated 8 times
Summary
This study tests a new drug (ceralasertib) alone or with either a targeted therapy (olaparib) or an immunotherapy (durvalumab) in 174 people with advanced gynaecological cancers that have returned after treatment. The goal is to see if these combinations work better in cancers with or without a specific gene change (ARID1A). Participants must have certain cancer types like clear cell or endometrioid ovarian or endometrial cancer.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Imperial College NHS Trust
London, United Kingdom
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Royal United Hospital
Bath, BA1 3NG, United Kingdom
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The Beatson
Glasgow, United Kingdom
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The Christie
Manchester, United Kingdom
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The Ottawa Hospital Cancer Centre
Ottawa, Ontario, K1H 8L6, Canada
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The Royal Marsden NHS Foundation Trust
London, SW3 6JJ, United Kingdom
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University of Montreal Hospital Centre
Montreal, Quebec, H2X 3E4, Canada
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Western General Hospital
Edinburgh, United Kingdom
Conditions
Explore the condition pages connected to this study.