New drug combo aims to keep rare lymphoma at bay after transplant

NCT ID NCT01908777

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving the drug romidepsin after a high-dose chemotherapy and stem cell transplant could help people with T-cell non-Hodgkin lymphoma stay in remission longer. Forty-seven patients participated. The goal was to see if this maintenance therapy improves progression-free survival at two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Romidepsin (Istodax)
What this could lead to: If successful, this approach could help keep T-cell lymphoma in remission longer after a stem cell transplant.
What could go wrong: This is a small, phase 2 study with only 47 participants. The drug may cause side effects, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

T-CELL NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

Fred Hutchinson Cancer Research Center (Data Collection Only)

Seattle, Washington, 98109, United States
Memorial Sloan Kettering Cancer Center

Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 11065, United States
Memorial Sloan Kettering Cancer Center @ Suffolk

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
University of Washington (Data Collection Only)

Seattle, Washington, 98109, United States
Weill Cornell Medical Center

New York, New York, United States

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