Can zapping cancer spots delay lung cancer progression?

NCT ID NCT05429320

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a procedure called local ablative therapy (LAT) can help control metastatic non-small cell lung cancer (NSCLC) when a blood test shows signs of remaining cancer (minimal residual disease, or MRD). 37 patients with stage IV NSCLC received LAT to all visible cancer sites. The goal was to see if LAT could reduce MRD levels and delay cancer growth compared to continuing standard therapy alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: local ablative therapy (LAT) - a procedure that destroys cancer cells using heat, cold, or radiation
What this could lead to: If successful, this approach could offer a way to delay cancer progression and extend the time before patients need stronger systemic treatments.
What could go wrong: This is a small, early-phase study (37 participants) with no control group in Part I. The treatment may not reduce MRD levels or improve survival, and side effects from ablation are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC NON-SMALL CELL LUNG CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Neoplasm, Residual non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC NON-SMALL CELL LUNG CANCER MINIMAL RESIDUAL DISEASE NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER METASTATIC NSCLC NSCLC STAGE IV

Contacts and locations

Locations

BAPTIST ALLIANCE - MCI (Data collection only)

Miami, Florida, 33143, United States
Hartford Healthcare ALLIANCE (Data collection only)

Hartford, Connecticut, 06102, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York, 10604, United States
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.