Memorial Sloan Kettering Cancer Center

This study tests whether combining the drug pembrolizumab with a precise form of radiation can cure people with early-stage Hodgkin lymphoma that has returned or not responded to initial treatment. About 22 participants will receive this combination, with the goal of avoiding the…

This study tests a condensed version of a chemotherapy regimen (busulfan, melphalan, fludarabine) plus an immune-suppressing drug (ATG) given before a donor stem cell transplant. The goal is to see if this shorter approach causes fewer severe side effects within 30 days after tra…

This study looks at whether not eating for at least 14 hours overnight (a form of intermittent fasting) is practical and can help improve blood sugar levels in adults who survived childhood cancer. Participants are randomly assigned to either follow this fasting schedule with coa…

This early-stage study tests whether combining a radioactive drug (177Lu-PSMA-617) with precise radiation therapy (SBRT) is safe for men with hormone-sensitive prostate cancer that has spread to a few other spots in the body. The drug seeks out and attacks cancer cells, while the…

This study tests whether taking enzalutamide for one year after standard treatment is practical for people with early-stage triple negative breast cancer that has androgen receptors. About 50 participants will take the drug and report on their quality of life. The main goal is to…

This early-stage trial tests a new treatment called MCARH109 for people with multiple myeloma that has come back or not responded to at least three prior treatments. The therapy uses specially modified immune cells to target a protein on the cancer cells. The main goal is to find…

This phase II trial tests whether adding canakinumab, an anti-inflammatory drug, to standard chemoradiation and immunotherapy (durvalumab) helps control locally advanced non-small cell lung cancer. About 41 participants will receive the combination to see if it improves progressi…

This phase 2 trial is testing a combination of four drugs (carfilzomib, lenalidomide, dexamethasone, and daratumumab) given before and after a stem cell transplant for people with multiple myeloma that has come back after prior treatment. The study includes 41 participants and ai…

This phase 2 trial investigates whether a program of regular walking and a plant-based diet can lower aromatase levels in overweight postmenopausal women with hormone receptor-positive breast cancer who are already taking an aromatase inhibitor. Participants are randomly assigned…

This trial investigates whether combining two drugs—BCG and gemcitabine—can safely and effectively treat a type of bladder cancer called non-muscle invasive bladder cancer (NMIBC) that has come back after previous BCG treatment. Participants receive BCG directly into the bladder …

This early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…

This early-phase trial tests whether adding venetoclax to a chemotherapy regimen originally designed for children is safe and effective for adults under 60 with newly diagnosed acute lymphoblastic leukemia (ALL). The study involves 12 participants and focuses on finding the right…

This phase II trial tests a humanized antibody called Hu3F8 combined with GM-CSF (a drug that boosts the immune system) in children and young adults with recurrent osteosarcoma, a type of bone cancer. The goal is to see if this treatment can extend the time before the cancer retu…

This early-phase trial tests the safety of giving patients modified immune cells from a donor to fight B-cell leukemia or lymphoma that has come back after a stem cell or organ transplant. The cells are designed to target a protein called CD19 on cancer cells. Only 19 patients ar…

This study tests whether combining pembrolizumab (an immunotherapy) with gemcitabine (a chemotherapy drug) can shrink tumors in people with advanced mycosis fungoides or Sézary syndrome, rare types of skin lymphoma. The trial enrolled 14 adults who had already tried at least one …

This early-phase trial tests whether a DNA vaccine made from a rat HER2 gene can safely stimulate the immune system in people with advanced or high-risk HER2-positive breast cancer. Thirteen participants receive multiple injections of the vaccine at different doses. The main goal…

This study tests a drug called abemaciclib in 33 people with dedifferentiated liposarcoma, a rare soft tissue cancer that has spread or cannot be removed by surgery. The drug aims to slow tumor growth or shrink it by at least a quarter. Abemaciclib is not yet approved for this ca…

This early-phase trial tests the safety of giving patients their own genetically modified T-cells to fight relapsed B-cell acute lymphoblastic leukemia. The study includes children and young adults up to age 26 whose leukemia has returned or is hard to treat. The modified T-cells…

This study tests whether placing tiny radioactive seeds (Cs-131) in the brain during surgery can stop recurrent brain tumors from growing back. About 103 adults with previously treated brain metastases will be randomly assigned to receive either surgery alone or surgery plus this…

This study tests whether people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) can safely stop taking acalabrutinib and obinutuzumab once their cancer responds very well, instead of continuing treatment indefinitely. The goal is to reduce serious side…

This study tests the drug lenvatinib in 33 people with advanced adenoid cystic carcinoma that has returned or spread. Lenvatinib is a daily pill that blocks cancer cell growth and cuts off blood supply to tumors. The main goal is to see if the drug can shrink tumors by at least 2…

This study tests whether adding two experimental vaccines (IO102/IO103) to the standard drug combination of nivolumab and relatlimab can shrink or control advanced melanoma that cannot be removed by surgery. About 43 adults with untreated stage III or IV melanoma will receive the…

This pilot study tests whether fecal microbiota transplantation (FMT) can safely reduce severe diarrhea caused by immune checkpoint inhibitors (ICIs) in cancer patients. Four adults who have persistent diarrhea despite steroids or other medications will receive a stool preparatio…

This phase II trial tests whether delivering chemotherapy directly into the liver (hepatic arterial infusion) along with standard IV chemo can shrink inoperable liver tumors from colorectal cancer enough to allow surgical removal. The study involves 64 participants whose cancer h…

This study looks at whether choosing stem cell donors based on certain genes (KIR) in addition to standard matching can reduce the chance of leukemia returning after a bone marrow transplant. About 511 people with acute myeloid leukemia (AML) are taking part. Doctors will test do…

This trial tests a vaccine designed to help the immune system recognize and attack neuroblastoma, a type of childhood cancer. The vaccine contains two antigens found on neuroblastoma cells, plus an adjuvant to boost the immune response. Participants also take an oral supplement c…

This study tests a program called SANOS that teaches Mexican adults how to eat healthy without spending a lot of money and how to be more active. About 1,785 overweight or obese participants will receive counseling and be followed for up to a year. The goal is to see if this appr…

This study tests whether adding daratumumab to a standard three-drug regimen (carfilzomib, lenalidomide, and dexamethasone) is safe and effective for people newly diagnosed with multiple myeloma. About 69 participants will receive the four-drug combination for eight cycles, follo…

This study tests two drugs, olaparib and pembrolizumab, given before standard surgery for people with triple-negative or hormone receptor-positive HER2-negative breast cancer who have specific gene mutations. The goal is to see if the combination can shrink tumors enough to impro…

This pilot study tests meclofenamate, a drug once used for pain, in 30 patients with brain metastases that have come back or grown despite prior treatments. The goal is to see if the drug can prevent new brain metastases and whether a larger trial is feasible. Researchers will mo…

This study looks at whether using ultrasound before surgery can help identify women with early-stage HR+/HER2- breast cancer who have only a few affected lymph nodes. If so, they may be able to have a less invasive sentinel lymph node biopsy instead of a more extensive axillary l…

This early-phase study tests whether giving a patient's own genetically modified immune cells (CAR T-cells) after high-dose chemotherapy and a stem cell transplant is safe for people with aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. Seve…

This early-phase trial is testing whether a device that delivers electric fields (TTFields) to lung tumors is safe and practical when used for 3 weeks before surgery. The study includes 12 people with early-stage lung adenocarcinoma. Researchers also want to see if this treatment…

This study tests whether giving radiation over just 5 days in a row, instead of the usual longer schedule, is safe and works well for breast cancer patients who have had a mastectomy and breast reconstruction. The goal is to prevent cancer from coming back in the chest or nearby …

This study tested a combination of two chemotherapy drugs, irinotecan and carboplatin, as the first treatment for children and adults newly diagnosed with intermediate- or high-risk rhabdomyosarcoma, a type of muscle cancer. The goal was to see if this drug pair could shrink tumo…

This study tests whether the drug iberdomide can safely improve outcomes for people with multiple myeloma who had a less-than-ideal response after a stem cell transplant and previous maintenance therapy. Sixteen participants will take iberdomide and be monitored for disease progr…

This early-phase study tests whether a new drug called AZD1390 is safe when given together with a precise type of radiation therapy (SBRT) for people whose solid tumors have spread to other parts of the body. The study involves 54 adults with metastatic cancer. The main goal is t…

This phase 2 trial is testing a five-drug combination for people with advanced esophageal, stomach, or gastroesophageal junction cancer that has worsened after initial treatment. The combination includes immune cells from healthy donors, two immunotherapy drugs, and two standard …

This early-phase study tests a new treatment called EGFR-BATs for people with advanced pancreatic cancer that has not responded to standard chemotherapy. The treatment uses the patient's own immune cells, which are trained in a lab to better attack cancer cells. The main goal is …

This study tests a new radiation technique called IMRT for people with malignant pleural mesothelioma, a rare lung cancer. The goal is to see if combining surgery, chemotherapy, and this targeted radiation is safe and reduces severe lung side effects. About 65 adults with early-s…

This study tests a new drug called ensartinib in people with advanced melanoma that has a specific genetic abnormality (ALK). The goal is to see if the drug can shrink tumors or stop them from growing for at least 24 weeks. Participants must be 18 or older and have already tried …

This phase 3 trial compares the standard chemotherapy docetaxel alone versus docetaxel plus radium-223 in 732 men with metastatic castration-resistant prostate cancer that has spread and stopped responding to hormone therapy. The goal is to see if adding radium-223 helps patients…

This phase 2 trial is testing whether combining radiation therapy with the immunotherapy drug cemiplimab can effectively treat locally advanced skin cancer that cannot be surgically removed. The study involves 34 participants who will receive both treatments over about 12 months.…

This study tests whether adding the drug durvalumab to targeted radiation (SBRT) can help keep early-stage non-small cell lung cancer from coming back. It included 13 people with stage I to IIIA disease. The main goal was to see how long they lived without their cancer getting wo…

This study tests whether adding the immunotherapy drug atezolizumab and targeted radiation (SBRT) to standard hormone therapy (abiraterone, prednisone, and leuprolide) is safe and works better for men with newly diagnosed metastatic prostate cancer that hasn't been treated yet. T…

This early study tests whether giving the drug Lutathera directly into the liver artery is safe and practical for people with neuroendocrine tumors that have spread mainly to the liver. Ten participants will receive two doses into the liver artery followed by two standard IV dose…

This early-phase study tests whether combining the immune-boosting drug nivolumab with a procedure that delivers chemotherapy directly to liver tumors (called deb-TACE) is safe for people with advanced liver cancer. Twenty participants will receive the combination, and researcher…

This phase 2 trial is testing whether adding doxorubicin to sorafenib can help people with advanced liver cancer whose disease has progressed while on sorafenib alone. The study enrolls 30 adults with confirmed liver cancer and Child-Pugh A cirrhosis or no cirrhosis. Researchers …

This early-phase trial tests whether adding a common water pill (bumetanide) to a standard procedure that blocks blood flow to liver tumors is safe and might help slow tumor growth. About 30 people with liver cancer that cannot be removed by surgery will take part. The study will…

This study tests a personalized approach to dosing two immunotherapy drugs (ipilimumab and nivolumab) for people with advanced melanoma. Instead of giving everyone four doses, doctors will check after two doses: patients who show early benefit may stop, while those who don't can …

This phase 2 trial tests whether giving a higher-than-standard dose of radiation, along with chemotherapy, can shrink pancreatic tumors enough to make them removable by surgery. The study includes 47 people with locally advanced pancreatic cancer that currently cannot be surgical…

This study tests whether giving a personalized dose of a drug called r-ATG before a stem cell transplant helps the immune system recover faster and reduces serious side effects. It includes children and adults with acute leukemia or myelodysplastic syndrome (MDS) receiving a dono…

This phase 2 trial tests whether N-acetylcysteine, a drug already used for acetaminophen overdose and lung mucus, can help severe COVID-19 patients by boosting their immune system. About 48 critically ill adults will receive the drug alongside standard care. The goal is to see if…

This study tests a new drug called ERAS-601 in 12 adults with advanced chordoma, a rare bone cancer that has gotten worse. The drug works by blocking a protein called SHP2, which may help slow or stop tumor growth. The main goal is to see if the drug is safe and can control the c…

This early-stage study tests a new approach for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to standard treatment. Researchers take a patient's own T cells, modify them in the lab to recognize and attack leukemia cells, and infuse th…

This study tests whether giving a mix of hormone-lowering medications (apalutamide, abiraterone, prednisone, and a GnRH drug) for a few months before surgery can shrink very high-risk prostate cancer and reduce the chance of it coming back. About 102 men with localized or low-vol…

This study tests whether combining two drugs, lenvatinib and pembrolizumab, can safely shrink or control advanced soft tissue sarcomas that have spread or can't be removed by surgery. About 52 adults with specific sarcoma types will receive the combination. The goal is to measure…

This early-stage study tests a drug called GDC-0084 given alongside radiation therapy for people whose cancer has spread to the brain and has a specific genetic mutation (PI3K). The main goal is to find the safest dose of the drug and see if the combination helps shrink tumors. O…

This study tests a pill called erdafitinib in 20 people whose non-muscle invasive bladder cancer has returned after standard treatments like BCG. All participants have a specific change in the FGFR3 gene, which the drug targets. They take the pill for about a month before their s…

This study tests whether the drug AG-120 can safely slow or stop the growth of a rare bone cancer called chondrosarcoma that has a specific IDH1 gene mutation. Six adults with advanced or recurrent grade 2 or 3 chondrosarcoma will receive the drug. The main goal is to see how lon…

This early-phase trial tests a new type of CAR T-cell therapy for adults with B-cell lymphoma that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified to better target and kill cancer cells. The study aims to find the safest dose a…

This study tests a combination of two drugs, epacadostat and pembrolizumab, in people with advanced sarcoma that has spread or cannot be removed by surgery. The goal is to see if the combo can shrink tumors. About 30 adults who have already tried at least one other cancer treatme…

This phase II trial tests whether a new imaging device (RCM/OCT) can help guide radiation therapy for basal cell carcinoma, a common skin cancer. About 38 participants will have their tumors imaged before radiation to see if this approach improves treatment accuracy and reduces s…

This phase II trial is testing whether adding two chemotherapy drugs, irinotecan and temozolomide, to the standard treatment for newly diagnosed Ewing sarcoma can improve outcomes. The study includes 83 patients aged 1 to 40. Researchers hope the extra drugs will help prevent the…

This early-phase trial tests whether adding glucarpidase (Voraxaze) to standard methotrexate and rituximab can safely lower methotrexate levels in the blood for people with central nervous system lymphoma. About 58 participants will receive different doses of methotrexate along w…

This early-phase trial tests a two-part treatment for people with relapsed or chemotherapy-resistant B-cell leukemia or lymphoma. First, patients receive a chemotherapy drug (cyclophosphamide) to help prepare the body. Then, they get an infusion of their own T cells that have bee…

This study tests a different dosing schedule of the chemotherapy drug capecitabine combined with the targeted therapy neratinib in people with advanced HER2-positive breast cancer. The goal is to find the safest dose that still works. About 34 adults with stage IV breast cancer t…

This study tests whether combining ruxolitinib and thalidomide can shrink the cancer and improve symptoms in 30 people with myelofibrosis, a rare bone marrow disease. Participants include those who have not responded to prior treatment or are newly diagnosed with higher-risk dise…

This study tests whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy works as well as the usual high dose (70 Gy) for people with HPV-positive throat cancer. The goal is to reduce long-term side effects while still controlling the cancer. About 316 …

This study aimed to see if combining three drugs—epcoritamab, lenalidomide, and tafasitamab—could safely treat diffuse large B-cell lymphoma that had come back or stopped responding to treatment. It was designed for adults with certain types of B-cell lymphoma. However, the trial…

This study tests a combination of targeted radiation (CART) and the immunotherapy drug avelumab in 18 people with advanced Merkel cell carcinoma that has spread or cannot be removed by surgery. The goal is to see if this approach can slow or stop the cancer from growing. Particip…

This study looks at adding the immunotherapy drug atezolizumab to standard chemotherapy (gemcitabine and cisplatin) for people with advanced or metastatic bladder cancer that cannot be removed by surgery. Researchers want to see if giving the drugs in a different order—chemothera…

This phase 2 trial is testing whether giving two immunotherapy drugs, nivolumab and ipilimumab, before surgery can shrink stage III melanoma tumors and prevent the cancer from returning. The 28 participants will also receive an experimental PET scan that images immune cells to se…

This early-phase study tests the safety of specially engineered immune cells (armored CAR T cells) in people with certain blood cancers that have not responded to standard treatments. The cells are made from the patient's own blood and designed to better target and attack cancer …

This phase 2 trial tests whether adding blinatumomab (an immunotherapy) to standard targeted therapy (dasatinib) can improve treatment for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to achieve a deep molecular response without…

This phase II trial tests the immunotherapy drug pembrolizumab in 39 people with advanced adrenocortical carcinoma that cannot be removed by surgery. The study aims to see if the drug can shrink or control the cancer. Participants receive pembrolizumab and are monitored for tumor…

This phase 2 trial tests whether isatuximab can help people whose blood cell counts stay low after a stem cell transplant for blood cancer. The study enrolls 12 adults whose disease is in remission but who have developed immune-related blood cell deficiencies. Participants receiv…

This study tests a personalized cell therapy called Ide-Cel (CAR T) in people with multiple myeloma who have already had a stem cell transplant. The goal is to see if the therapy can be made successfully and help prevent the cancer from returning. About 24 participants will recei…

This pilot study tests whether combining glofitamab (an IV drug) with lenalidomide (an oral drug) is a feasible treatment for people with mantle cell lymphoma that has returned or not responded to prior therapy, including a BTK inhibitor. The study enrolls 39 adults and focuses o…

This study tests a drug called CPI-613 in people with relapsed or hard-to-treat Burkitt lymphoma or high-grade B-cell lymphoma. About 24 participants aged 12 and older who have not responded to at least one prior treatment will receive the drug. The goal is to see if the drug can…

This phase II trial is testing whether a pre-treatment biopsy can predict how well patients with locally recurrent or metastatic triple negative breast cancer respond to cisplatin chemotherapy combined with radiation therapy. About 49 participants will receive the treatment, and …

This early-phase trial is testing whether combining the immunotherapy drug pembrolizumab with a precise type of radiation (IMPRINT) is safe for people with malignant pleural mesothelioma, a rare cancer of the lung lining. The study involves 7 participants whose cancer cannot be r…

This study tests whether combining an immunotherapy drug (nivolumab) with standard chemotherapy (FOLFOX) and a targeted therapy (regorafenib) can safely control HER2-negative metastatic esophagogastric cancer. About 39 adults with advanced cancer that has spread will receive the …

This early-phase study tests a new way to calculate the dose of the chemotherapy drug melphalan for lymphoma patients about to receive a stem cell transplant. Instead of a fixed dose based on height and weight, researchers use a model that considers how previous patients processe…

This study tests the safety and effectiveness of pembrolizumab, an immunotherapy drug, in 17 adults with MSI-H solid tumors who still have cancer DNA in their blood after surgery. Participants receive the drug every 3 weeks for up to 12 months. The main goal is to see if the drug…

This early-phase trial tests a new treatment for multiple myeloma, a type of blood cancer. It uses a patient's own immune cells, modified to target a protein called BCMA on cancer cells, and may be combined with a drug called lenalidomide. The main goal is to find the safest dose…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to bone tumors before surgery is safe and can prevent the cancer from returning. About 39 adults with cancer that has spread to their bones and who need surgery to stabilize a fracture risk will recei…

This phase 2 trial is testing a drug called ado-trastuzumab emtansine (Kadcyla) in 131 adults with advanced solid tumors that have a specific HER2 gene change. The drug combines an antibody that targets HER2 with a chemotherapy agent, aiming to deliver treatment directly to cance…

This pilot study tests whether the drug pembrolizumab can shrink or control recurrent malignant glioma, a type of brain cancer, in people whose tumors have many genetic mutations (hypermutator phenotype). The 27 participants have already had radiation and chemotherapy. The goal i…

This study tests whether a surgical technique called immediate lymphatic reconstruction can prevent lymphedema (arm swelling) in breast cancer patients who need lymph node removal. About 180 women will be randomly assigned to receive either standard lymph node removal alone or wi…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can shrink tumors or slow cancer growth in people with advanced uterine or ovarian carcinosarcoma, a rare and aggressive cancer. About 40 participants will receive the treatment, and researchers will also…

This study tests whether taking pancreatic enzymes (Pertzye) with meals can help people with metastatic pancreatic cancer maintain their body weight during chemotherapy. The trial includes 17 participants who are starting a standard chemo regimen called FOLFIRINOX. Researchers wi…

This early-phase study tests a combination of three drugs—belantamab mafodotin, nirogacestat, and pomalidomide—in people with multiple myeloma that has returned or stopped responding to treatment. The main goal is to find the safest dose of belantamab when given with the other tw…

This study is testing whether giving a lower dose of radiation to a smaller area after surgery for soft tissue sarcoma works as well as the standard approach. The goal is to control the cancer while causing fewer long-term side effects. The trial includes 65 adults who had their …

This study tests whether a geriatric assessment—looking at thinking, mobility, mood, nutrition, and medications—can help doctors choose the right transplant intensity for patients aged 60 and older with myeloid blood cancers. The goal is to reduce deaths from transplant complicat…

This study tests whether combining two drugs, pembrolizumab and olaparib, can help people with a specific type of advanced pancreatic cancer keep their disease from growing. The trial includes 63 adults whose cancer has a genetic flaw called HRD or has responded well to platinum …

This phase 2 study tests whether amivantamab can shrink tumors in people with esophagogastric cancer that has a specific genetic change (EGFR or MET amplification). About 25 participants who have already tried at least one other treatment will receive the drug intravenously. The …

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy (ABVD) can improve cure rates for people with high-risk Hodgkin lymphoma. About 82 participants with untreated stage III or IV disease are enrolled. The Phase I part checks safety and side e…

This study tests whether giving immunotherapy drugs (nivolumab alone or with ipilimumab) before bladder cancer surgery is safe and does not delay the operation. The goal is to shrink the tumor, making surgery more effective. It involves 52 adults with muscle-invasive bladder canc…

This study tests a combination of two drugs, vemurafenib (a pill) and obinutuzumab (an infusion), in 30 people with previously untreated hairy cell leukemia. The goal is to see how many patients achieve a complete response, meaning no signs of cancer after treatment. Participants…

This study looks at whether people with multiple myeloma who have been in a deep remission (called MRD-negative) for at least 3 years can stop their maintenance therapy and just be monitored closely. The goal is to see if stopping treatment keeps the cancer under control for at l…

This study tests a cream containing ruxolitinib, a drug that targets inflammation, for treating a chronic skin condition called graft-versus-host disease (GVHD) that can occur after a stem cell transplant. About 24 participants will apply the cream to one side of their body and a…

This study compares two ways of giving chemotherapy directly into the belly after surgery to remove visible cancer from the lining of the abdomen. The cancer comes from the appendix, colon, or rectum. About 292 adults will be randomly assigned to receive either early post-operati…

This study tests whether giving stereotactic body radiotherapy (SBRT) to growing metastatic tumors can delay overall cancer progression. About 107 adults with triple-negative breast cancer or non-small cell lung cancer that has started to grow in a few spots will receive SBRT or …

This study tests whether giving a second dose of the CAR T-cell therapy tisagenlecleucel early can keep the immune system's B cells low for at least 6 months in children and young adults with relapsed B-cell acute lymphoblastic leukemia. The goal is to reduce the chance of the ca…

This phase II study tests whether giving an extra-high radiation dose directly to the main prostate tumor, while treating the rest of the prostate with standard SBRT, can reduce the chance of cancer coming back. About 91 men with intermediate-risk prostate cancer will receive fiv…

This phase 2 trial tests two immunotherapy drugs, durvalumab and tremelimumab, in 30 adults with relapsed or refractory germ cell tumors. The goal is to see if the combination can shrink tumors or lower tumor markers. Participants must have measurable disease and have progressed …

This study looks at whether people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have undetectable cancer cells after venetoclax treatment can stop taking the drug and stay in remission for at least a year. Researchers will monitor 81 participant…

This early-phase study tests HB-200 (a combination of two investigational drugs) in 7 people with HPV16-positive head and neck cancer who have completed standard treatment but still show signs of HPV DNA in their blood. The goal is to see if HB-200 can target and eliminate any re…

This phase II trial tests how well chemoradiation (using fluorouracil, leucovorin, and oxaliplatin) works before surgery for stage II or III rectal cancer. The study looks at different time intervals between chemoradiation and surgery to see which timing leads to the best tumor s…

This phase 2 trial is testing the safety and effectiveness of glipizide, a standard diabetes drug, for lowering blood sugar in people with pancreatic cancer. The study includes 29 participants with active pancreatic cancer and high blood sugar. Researchers will measure blood suga…

This phase 2 study tests a combination of two drugs—nivolumab (an immunotherapy) and a radioactive antibody called 177Lu-girentuximab—in people with advanced clear cell kidney cancer that has the CAIX protein. The goal is to find the safest dose and see if the combination shrinks…

This early-stage trial tests whether a patient's own immune cells can be genetically modified to recognize and attack prostate cancer cells. Thirteen men with advanced prostate cancer that no longer responds to hormone therapy will receive infusions of their own engineered T cell…

This study tests a combination of two drugs—an antibody called Hu3F8 and a growth factor called GM-CSF—in children with high-risk neuroblastoma that has come back or not responded to standard therapy. The goal is to find the safest dose and understand side effects. About 186 part…

This study tests whether giving palifermin and leuprolide acetate can help the immune system recover more quickly after a stem cell transplant for blood cancers like leukemia and lymphoma. About 82 participants will receive these drugs alongside their transplant. The goal is to s…

This phase II trial tests whether adding the immunotherapy drug nivolumab to re-irradiation and bevacizumab can help people with recurrent glioblastoma live longer. The study includes 39 participants whose tumors have a specific genetic marker (MGMT methylated). The goal is to se…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy (gemcitabine and cisplatin) is safe and works better for people with advanced bladder cancer. About 54 participants will receive the combination treatment. The goal is to see if the combo…

This early-phase trial is testing whether a personalized cancer vaccine, combined with an immunotherapy drug (atezolizumab) and chemotherapy, is safe for people with pancreatic cancer that has been surgically removed. The vaccine is made specifically for each patient based on the…

This study tested whether adding the targeted drug cetuximab to standard chemotherapy could shrink advanced thymoma or thymic carcinoma tumors before surgery. 18 adults with stage II to IVA disease received the combination, then had surgery to remove any remaining tumor. Research…

This pilot study tests whether adding plinabulin to the standard drug pegfilgrastim can shorten the time that white blood cell counts stay dangerously low after a stem cell transplant in people with multiple myeloma. Seventeen participants will receive both drugs right after thei…

This early study tests a drug called romosozumab in 10 postmenopausal women who have both multiple myeloma and osteoporosis. The goal is to see if it safely improves bone formation and reduces bone breakdown caused by the cancer. Researchers will measure bone health markers and w…

This study tests the safety of combining the drug RP-3500 with radiation therapy for people whose cancer has spread and who have a specific gene change (ATM mutation). About 49 adults with advanced solid tumors will receive the combination to find the safest dose and see if it he…

This study tests the safety and effectiveness of neratinib, a targeted cancer drug, in children whose solid tumors, brain tumors, lymphoma, or leukemia have come back or not responded to standard treatments. The drug is taken by mouth daily in 28-day cycles. The main goal is to f…

This study tests a combination of two drugs, MEK162 and imatinib (Gleevec), in people with advanced gastrointestinal stromal tumor (GIST). The first part finds the safest dose, and the second part checks how well the combo shrinks tumors. About 75 participants will take part, inc…

This phase 2 trial is testing whether the oral chemotherapy drug ixazomib can help control AL amyloidosis after initial treatment. Seventeen adults with the disease will take ixazomib along with low-dose dexamethasone to see if it delays organ progression or the need for more the…

This study tests whether combining two drugs (lenalidomide and CC-486) with radiation therapy is safe and works well for people with plasmacytoma, a tumor made of plasma cells. About 21 adults with newly diagnosed or returning plasmacytoma will take part. The main goal is to see …

This early-phase study tests a combination of three drugs (rituximab, bendamustine, and melphalan) followed by a stem cell transplant using the patient's own cells. The goal is to see if this approach is safe and has fewer side effects than standard treatments for older adults wi…

This study looks at whether giving more stem cells during an autologous transplant helps people with relapsed or refractory diffuse large B-cell lymphoma recover better and stay cancer-free longer. About 59 adults who have already tried one chemotherapy will get high-dose chemo (…

This phase 2 study tests whether combining the immunotherapy drug durvalumab with radiation therapy (without chemotherapy) can delay cancer worsening in people with locally advanced non-small cell lung cancer. About 61 participants will receive radiation plus durvalumab infusions…

This study tests whether adding an experimental drug called PEGPH20 to standard chemotherapy can help shrink advanced pancreatic cancer. PEGPH20 breaks down hyaluronan, a substance that builds up in pancreatic tumors and may help them grow. The trial includes 110 people with adva…

This study looks at which treatments work best to help smokers reduce or quit smoking when they come for lung cancer screening. About 800 patients at lung cancer screening sites across the U.S. are taking part. The goal is to find a simple, effective approach that screening sites…

This phase 2 study is testing whether combining two drugs, rucaparib and nivolumab, can treat advanced or metastatic leiomyosarcoma (LMS), a rare soft-tissue cancer. The 20 participants take rucaparib pills twice daily and get nivolumab infusions every four weeks. The main goal i…

This early-phase study tests whether combining two cancer drugs (cabozantinib and nivolumab) with precise radiation is safe for people with kidney cancer that has spread to the brain. Only 2 participants were enrolled, and the main goal is to see if they can tolerate the treatmen…

This study tests whether the drug anakinra can prevent or reduce severe side effects like brain problems and cytokine release syndrome caused by CAR-T cell therapy. About 62 adults with certain B-cell blood cancers who are getting CAR-T treatment will receive anakinra. The goal i…

This study tests whether combining two immune-boosting drugs, pembrolizumab and BCG, can keep high-risk bladder cancer from coming back. About 45 people with early-stage but aggressive bladder cancer will receive this combination as their first treatment. The goal is to see if mo…

This phase 2 trial is testing whether a shorter course of hormone therapy (6 months instead of the usual longer duration) combined with targeted radiation can safely prevent high-risk prostate cancer from spreading. About 50 men with aggressive prostate cancer will receive hormon…

This early-phase study tests whether giving radiation therapy before standard CAR T cell treatment is safe and practical for people with B-cell lymphoma that has come back or not responded to prior treatments. About 20 participants will receive split-course bridging radiation to …

This early-phase trial tests whether adding N-Acetylcysteine (N-AC), an antioxidant, to standard CAR T-cell therapy (Yescarta) is safe for people with lymphoma. Nine participants receive different doses of N-AC to find the highest dose with few side effects. The goal is to see if…

This early-phase study tests a combination of two drugs—TTI-622 and daratumumab—in people whose multiple myeloma has returned or is not responding to treatment. The main goal is to find a safe dose of TTI-622 when given with daratumumab. Only 7 participants are enrolled, so the f…

This early-phase trial tested whether giving a second, single dose of highly focused radiation is safe for people with spine tumors that have grown back after previous radiation. Nine adults with certain types of cancer took part. The goal was to find the highest safe dose and wa…

This study tests whether a very low-carb (ketogenic) diet, a low-carb diet, or the diabetes drug canagliflozin can prevent high blood sugar and possibly make standard cancer therapy more effective. It involves 15 people with advanced, hormone-receptor-positive breast cancer that …

This phase 2 study tests a combination of two drugs—talimogene laherparepvec (T-VEC), a virus that attacks cancer cells, and pembrolizumab, an immunotherapy that helps the immune system fight cancer—in 41 adults with advanced sarcoma that has spread or cannot be removed by surger…

This pilot study tests whether the immune-boosting drug pembrolizumab can shrink early-stage NK/T-cell lymphoma in patients who have not yet had chemotherapy. Nineteen participants will receive the drug every three weeks. The goal is to see if this approach can control the diseas…

This study tests a drug called niraparib in people with advanced soft tissue sarcoma that has certain DNA repair gene changes. The goal is to see if the drug can stop or slow tumor growth. About 8 adults with inoperable or metastatic sarcoma will take niraparib pills and be monit…

This study tests whether combining two drugs—etrumadenant and zimberelimab—can shrink or slow advanced dedifferentiated liposarcoma that has returned, spread, or can't be removed by surgery. About 16 adults with this rare cancer will receive the treatment. The goal is to see how …

This phase 2 trial tests whether adding an experimental drug (BMS-986205) to the immunotherapy nivolumab can shrink tumors or prevent cancer from returning in people with recurrent endometrial cancer. About 24 participants will receive the combination. The study compares this com…

This study tests whether combining two drugs, palbociclib and INCMGA00012, is safe and effective for people with advanced liposarcoma, a rare cancer of fat cells. About 42 participants with tumors that cannot be removed by surgery or have spread will receive the combination. The …

This study is testing a combination of two drugs, venetoclax and obinutuzumab, in people with chronic lymphocytic leukemia (CLL) who have not yet had treatment. The goal is to see how well this therapy controls the disease and improves survival. About 100 fit adults with CLL will…

This study tests a new, more stable version of the chemotherapy drug melphalan in people with multiple myeloma or AL amyloidosis who are getting a stem cell transplant. The goal is to find the best dose that reaches a target level in the body, while possibly causing fewer side ef…

This study compares two smoking cessation programs for newly diagnosed cancer patients who smoke. One group gets counseling plus a nicotine patch, while the other adds a scheduled reduced smoking program before quitting. The goal is to see which approach helps more patients quit …

This study tests whether two drugs, lenvatinib and pembrolizumab, can shrink or slow the growth of advanced salivary gland cancers, including adenoid cystic carcinoma, that have come back or spread. About 64 participants will receive the combination therapy. The goal is to see ho…

This study tests a treatment using a patient's own immune cells (T cells) that are genetically modified to recognize and attack a protein called mesothelin found on cancer cells. The treatment is given through a tube in the chest to people with malignant pleural disease, includin…

This study tests whether adding the immunotherapy drug durvalumab to focused radiation (SABR) can help people with locally advanced pancreatic cancer. The goal is to shrink tumors enough to allow surgery. The trial includes 18 participants who have already received standard chemo…

This study tests whether a precise type of radiation called SBRT can restore the effectiveness of immunotherapy drugs in people whose metastatic cancer has started to progress. About 69 adults with melanoma, lung, bladder, kidney, or head/neck cancers will receive radiation to up…

This phase 2 trial tests a combination of the immunotherapy drug PDR001 with either trametinib or dabrafenib in 19 patients with thyroid cancer that no longer responds to radioiodine treatment. The goal is to see if the combination can shrink tumors. The study is active but no lo…

This early study tests if a laser can safely destroy small thyroid cancers (papillary thyroid microcarcinoma) without removing the thyroid. Ten adults with small tumors will receive laser treatment, then have their thyroid removed 6 months later to check if the cancer is fully go…

This study tests a shorter radiation treatment (partial breast irradiation) for women with early-stage breast cancer or a pre-cancer called DCIS. Instead of treating the whole breast for 5-7 weeks, radiation is given only to the area where the tumor was removed, for just 2 weeks.…

This early-phase study tests a new, ultra-short course of radiation therapy for men with intermediate-risk prostate cancer. The treatment uses MRI guidance to precisely target the prostate and the main tumor inside it. The goal is to see if this approach is safe and practical, wi…

This phase 2 trial tests whether combining NKTR-214 and nivolumab can shrink or control advanced sarcoma that has spread. About 88 people aged 12 and older with certain sarcoma types will receive both drugs every three weeks. The main goal is to see how many patients have their t…

This study tests two drugs, nivolumab and cabozantinib, together in 60 people with advanced or metastatic non-clear cell kidney cancer. The goal is to see how well the combination shrinks tumors. Participants take cabozantinib daily and receive nivolumab infusions every two weeks…

This phase 2 trial is testing whether a combination of chemotherapy drugs typically used in children can be safe and effective for adults aged 18 to 60 with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL). The study aims to see if this 'pediatr…

This early study tests whether giving nivolumab (an immunotherapy) along with standard chemotherapy before surgery is safe and feasible for people with malignant pleural mesothelioma. The main goal is to see if this approach delays surgery by more than 30 days. 22 participants wi…

This early-phase trial is testing a personalized cell therapy called lifileucel in 10 people with melanoma that has spread to the brain and is no longer responding to standard immunotherapy. Doctors remove a piece of the tumor, grow the patient's own immune cells in the lab, and …

This phase 2 trial compares daratumumab and lenalidomide as maintenance therapy for people with newly diagnosed multiple myeloma who have responded well to initial treatment. The main goal is to see which drug provides better health-related quality of life, measured through quest…

This early-phase trial adds three drugs—irinotecan, temozolomide, and bevacizumab—to the usual chemotherapy for newly diagnosed desmoplastic small round cell tumor (DSRCT), a rare and aggressive cancer. The study includes 15 patients aged 1 to 30 and aims to see if the combinatio…

This study tests adding the immunotherapy drug durvalumab to standard chemoradiation for people with esophageal or gastroesophageal junction cancer. About 64 participants will receive the combination to see if it is safe and effective. The goal is to improve cancer control withou…

This study tests a new imaging tracer called 18F-TFB to see if it can show how well thyroid cancer cells take up radioactive iodine. The goal is to get results faster than current methods and without affecting later treatment. About 5 adults with thyroid cancer will receive the t…

This phase 1 trial tests whether a new radioactive imaging agent, 89Zr-ss-pertuzumab, is safe for detecting HER2-positive breast cancer in 60 participants. The agent is designed to bind to HER2 proteins on cancer cells and show up on PET/CT scans. The main goal is to check for si…

This study is testing a new technology called breathprinting, or electronic nose (e-nose), to see if it can detect early-stage lung cancer. Researchers will collect breath samples from 119 people with suspicious lung nodules before they have a biopsy or surgery. The goal is to se…

This study tests a new dye, called cRGDY-PEG-Cy5.5-C dots, to help surgeons see cancer in lymph nodes during head and neck melanoma surgery. About 67 people will receive the dye injection around their tumor before or during surgery. The dye is not a treatment, but may improve how…

This study is testing a new imaging method called Cerenkov luminescence imaging, which uses light naturally given off by certain radioactive substances used in standard cancer scans. Researchers want to see if this technique can take clear pictures of thyroid cancer and tumors th…

This study aims to develop a blood test that predicts how well a patient's advanced pancreatic cancer will respond to different chemotherapy regimens. Researchers will analyze circulating tumor cells (CTCs) from 74 participants to see if the test can identify the most effective t…

This study tests a new type of DCE-MRI that takes pictures faster and reduces blurring from movement. The goal is to see if it gives clearer images of gynecologic tumors than traditional MRI. About 24 women with gynecologic cancer and healthy volunteers will take part. The new sc…

This study tests whether a new imaging technique called multispectral optoacoustic tomography (MSOT) can visualize breast cancer and melanoma tumors. Twelve participants will have MSOT scans before their standard biopsy or treatment. The goal is to see if MSOT can detect tumors a…

This study tests a fluorescent dye called PARPi-FL that may make oral cancer cells glow during an endoscopic exam. About 23 people with oral squamous cell carcinoma will gargle the dye before surgery, and doctors will check for safety and how well the dye highlights tumors. It is…

This study explores whether routine brain MRIs and spinal taps can detect early signs of breast cancer spreading to the brain in people with HER2-positive breast cancer. Researchers will enroll 9 participants to see if these tests are feasible and well-tolerated. The goal is to c…

This study is testing a new, non-invasive camera that takes detailed images of skin lesions to see if it can detect skin cancer without needing a biopsy. Researchers are collecting images from nearly 1,900 people with skin lesions and comparing them to standard biopsy results. Th…

This study tests a new radioactive dye attached to tiny silica particles to improve PET scans for people with melanoma or malignant brain tumors. Ten participants will receive a single injection of the tracer to see how it spreads in the body and how much radiation it gives off. …

This study tests whether injecting a radioactive sugar tracer (18F-FDG) into the cervix before a PET/CT scan can better show which pelvic lymph nodes contain cancer in women with early-stage cervical or high-grade endometrial cancer. The goal is to improve surgical planning by mo…

This early-phase study is testing whether a special PET scan (68Ga-PSMA-11) can effectively show tumor activity in people with high-grade gliomas or brain metastases. About 11 adults whose tumors are at least 1 cm and who are already scheduled for a biopsy or surgery will receive…

This study tests whether a dye called indocyanine green (ICG) used with near-infrared imaging can find sentinel lymph nodes as well as the standard radioactive tracer method in people with early-stage vulvar cancer. About 22 participants will receive both methods during surgery t…

This pilot study tests whether a special dye and near-infrared camera can help surgeons see blood flow in tissue flaps used for reconstruction after gynecologic cancer surgery. Fifteen women will receive an ICG dye injection during surgery, and the surgeon will use the images to …

This early study tests a new radioactive drug called [18F] Fluoroglutamine, which is designed to be used with PET scanners. Researchers want to see how long it stays in the blood and where it goes in the body, especially whether it collects in tumors. 67 adults with solid cancers…

This study looks at whether a breast MRI-guided biopsy can accurately tell if a woman's breast cancer has completely disappeared after chemotherapy. Researchers will enroll 31 women whose tumors are no longer visible on MRI after treatment. If the biopsy correctly identifies a co…

This study is testing whether a blood test called NavDx can find HPV-related oropharyngeal cancer early by looking for HPV DNA in the blood. Researchers are enrolling adults aged 45 and older with multiple sexual partners who have no history of this cancer. Participants give bloo…

This study aimed to test a new two-step PET imaging method to better detect cancers that produce a substance called CA19-9, such as pancreatic, bladder, and gastrointestinal tumors. The plan was to give patients an antibody followed by a radioactive tracer to highlight cancer cel…

This early-phase trial at Memorial Sloan Kettering is testing whether a special PET scan using an experimental tracer called 18F-FAC can show how much of the standard chemotherapy drug gemcitabine is taken up by pancreatic tumors. About 30 people with pancreatic ductal adenocarci…

This study tests new MRI techniques to reduce image problems caused by movement during scans. Researchers will add short experimental sequences to routine MRIs in 21 patients of any age at Memorial Sloan Kettering. The goal is to compare image quality and see if these new methods…

This study is testing whether a type of PET scan called PSMA PET is more accurate than standard scans (like CT or bone scans) for monitoring prostate cancer. About 58 men with progressive prostate cancer will receive an injection of a radioactive tracer and then undergo PET/CT im…

This early-phase trial is testing the safety of a new imaging drug called [18F]PARPi in 12 people with head and neck cancer. The drug is designed to make cancer cells show up more clearly on PET/CT scans. The goal is to see if this approach can provide better pictures of tumors t…

This study tests whether adding N-Acetylcysteine (NAC) to the standard drug amiodarone can better prevent atrial fibrillation (a type of irregular heartbeat) in people at high risk after major chest surgery. About 184 adults having lung or esophagus surgery will be randomly assig…

This study tests whether a short educational session plus weekly text reminders can increase HPV vaccination rates among children of Mexican-American parents. About 672 parents will be randomly assigned to receive either education alone or education plus text reminders. The goal …

This study tested whether a social marketing campaign—with or without text message reminders—could increase the number of Mexican American children ages 9 to 17 who complete the full 3-dose HPV vaccine series. About 181 parents in the New York City area took part. The goal was to…

This study explores whether aerobic exercise, like walking, can lower levels of ctDNA (a marker of cancer in the blood) and help prevent breast, prostate, or colorectal cancer from coming back. Researchers will test different amounts of weekly exercise (90 to 375 minutes) in 33 p…

This study tests whether giving patients their own preserved stool (collected before a stem cell transplant) can prevent Clostridium difficile infection afterward. About 59 adults receiving an allogeneic stem cell transplant are randomly assigned to get the stool transplant or st…

This study tests whether sending personalized print materials and a follow-up phone call can encourage women who had childhood cancer to get mammograms. Participants are 360 women aged 25-49 who received chest radiation as children and haven't had a mammogram in two years. The go…

This study tests whether a plant-based diet is practical for overweight people with MGUS or smoldering multiple myeloma, conditions that can lead to multiple myeloma. For 12 weeks, 23 participants receive two pre-made plant-based meals daily. Researchers track weight loss and die…

This study tests whether an over-the-counter herbal pain patch, called Tibetree Pain Relieving Plaster, can reduce muscle and joint pain in people who have finished active cancer treatment. Sixty-eight cancer survivors will apply either the active patch or a placebo patch to thei…

This study tests a new type of talk therapy (Emotion Regulation Therapy) against standard cognitive behavioral therapy for people caring for a loved one with cancer. About 348 caregivers will participate to see which approach better reduces anxiety, depression, and stress. The st…

This study looks at whether providing food assistance—like vouchers, grocery delivery, or a hospital food pantry—helps cancer patients finish their treatment. About 600 patients with breast cancer who struggle to afford food will be randomly assigned to one of three programs. Res…

This study tested if a scalp cooling cap set to a colder temperature than usual can safely prevent hair loss in breast cancer patients receiving chemotherapy. 34 adults with stage I-III breast cancer took part. The goal was to see if the lower temperature is safe and tolerable.

This study tests a new counseling program called Meaning-Centered Grief Therapy (MCGT) for parents who have lost a child. The program focuses on helping parents find meaning and purpose after their loss. About 108 parents will take part, and the study will see if the therapy is p…

This study compares standard in-person follow-up care with telemedicine (phone or video visits) for people who have finished treatment for HPV-related throat cancer and show no signs of cancer on scans. The goal is to see which approach better maintains quality of life, detects a…

This study compares group telemedicine appointments to individual video visits for men with prostate cancer who are on active surveillance. Researchers want to see if the group format is practical and acceptable, and how it affects patient satisfaction and quality of life. The st…

This study adapts a type of counseling called Meaning-Centered Psychotherapy for Chinese immigrants with advanced cancer. The goal is to help patients maintain a sense of meaning and purpose in life despite their illness. Researchers will interview and test the adapted program wi…

This phase 2 study tests whether acupuncture can improve memory, focus, and thinking problems (often called 'chemo brain') in people who have had breast, colorectal, prostate, or gynecological cancer. About 48 participants will receive either real acupuncture or sham (fake) acupu…

This study tests whether a telemedicine program is a practical way to address the unique needs of adults aged 70 and older who are receiving cancer treatment. Participants meet with a geriatric nurse via video calls over three months to discuss symptoms and aging-related concerns…

This pilot study tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS), combined with cognitive training, is feasible and tolerable for breast cancer survivors who have memory or thinking problems after chemotherapy. The st…

This study looks at whether an 8-week digital program called COBRA, which includes balance and resistance exercises, is safe and practical for older adults with cancer. The program is delivered via an iPad with video calls. Researchers will track how many participants stick with …

This study develops and tests a mobile app to help breast cancer and rare cancer survivors manage their fear of the cancer coming back. About 252 participants will try one of three app versions to see which is most helpful and easy to use. The goal is to create a personalized too…

This study tests whether acupuncture can improve thinking problems (like memory and focus) in breast cancer survivors. About 270 women who have finished cancer treatment will receive either real acupuncture, sham acupuncture, or standard care. Researchers will track their cogniti…

This early-phase trial tests a treatment called vascular-targeted photodynamic therapy (VTP) for people with advanced esophageal or stomach cancer who have moderate to severe trouble swallowing. The treatment uses a light-sensitive drug (WST-11) and a laser delivered through a th…

This study tests whether a smartphone app that sends text reminders can help breast cancer patients take their medication (palbociclib) on time. 45 participants will either use a paper diary or receive text reminders over three treatment cycles. The goal is to see if the app is e…

This study looks at whether giving men a deeper level of muscle relaxation during robotic prostate surgery can lower the pressure used during the operation and reduce pain afterward. About 139 men having this surgery will be randomly assigned to either deep or moderate muscle rel…

This study tests whether a game-based exercise plan can increase physical activity in childhood cancer survivors aged 10 to 16. The child and a parent or caregiver both take part in the program. Researchers will also see if the plan improves the child's quality of life. The goal …

This study compares two common surgeries for people whose thigh bone has been weakened by cancer spread. One surgery replaces the hip joint, the other uses a rod inside the bone. Researchers want to see which one leads to better function, quality of life, and pain control after s…

This pilot study tests whether oral minoxidil can improve persistent hair loss in children and young adults who survived cancer. Ten participants aged 6-18 who completed cancer treatment at least a year ago will receive either minoxidil or a placebo for 4 months. Researchers will…

This study compares two methods of prepectoral breast reconstruction after mastectomy for breast cancer: one using acellular dermal matrix (ADM) and one without. The goal is to see if using ADM leads to fewer major complications like infection or implant removal within 90 days. A…

This pilot study tests whether a pelvic floor muscle exercise program, taught by a physical therapist before and after radical prostatectomy, is feasible and acceptable for men with prostate cancer. The researchers will track how many patients join, stick with the program, and co…

This study compares two group programs for breast cancer survivors: a Meaning-Centered Group that helps women find purpose after cancer, and a Discussion Group that offers peer support. About 104 survivors who have finished treatment (except hormone therapy) will take part. The g…

This study looks at ways to prevent and reduce radiation esophagitis—painful inflammation of the swallowing tube—in 142 cancer patients receiving chest radiation. Researchers will test a two-step consent process and measure whether the approach cuts the need for strong painkiller…

This study tests whether giving methadone during spinal surgery helps control pain for the first 72 hours after surgery better than standard pain medicines. Seventeen adults having cancer-related spinal surgery took part. Researchers measured pain scores and how much extra pain m…

This pilot study tests whether a personalized home exercise program is practical and helpful for women with advanced ovarian cancer who are receiving chemotherapy before surgery. Twenty-two participants will follow daily exercises and weekly coaching until their operation. The ma…

This study tests a communication program for people with advanced cancer and their caregivers. The goal is to help them manage difficult emotions and talk about the patient's illness and treatment wishes. About 45 participants will take part, and the program is tailored for Latin…

This study compares personalized electro-acupuncture and auricular-acupuncture against usual care for treating chronic pain in adults with musculoskeletal pain or fibromyalgia. Participants are split into three groups: two receive different acupuncture methods, and one receives s…

This study compares proton beam radiation to standard photon radiation (IMRT) for people with head and neck cancer. The goal is to see if proton therapy causes fewer side effects, like painful mouth sores, by exposing less healthy tissue to radiation. About 108 adults with certai…

This study looks at whether flibanserin, a drug for low sexual desire, can be safely taken by breast cancer survivors who are on tamoxifen or similar hormone therapies. About 43 women with a history of breast cancer and no current disease will take flibanserin for 24 weeks. The m…

This study compares two ways of giving high-dose radiation to people whose cancer has spread to bones, spine, soft tissue, or lymph nodes. One schedule gives the radiation in one day, the other over three days. The goal is to see which schedule better controls tumor growth and ha…

This study tests whether a drug called siltuximab can reduce symptoms like weakness, fatigue, nausea, and pain after a stem cell transplant in patients aged 60-75 with multiple myeloma or AL amyloidosis. The drug blocks a protein linked to inflammation, which may help patients re…

This study looks at whether adding personalized supportive care (like help with symptoms and emotional concerns) to standard treatment helps people with advanced solid tumors who are starting early-phase cancer drug trials. About 83 participants will be randomly assigned to recei…

This study tests whether adding acupuncture to standard pain care can reduce the need for strong opioid painkillers in people with multiple myeloma, Hodgkin disease, or non-Hodgkin lymphoma who are getting high-dose chemotherapy. About 299 adults will be randomly assigned to rece…

This pilot study tests whether acupuncture can reduce frequent nighttime urination (nocturia) in prostate cancer survivors. Researchers will give 60 participants up to 10 acupuncture sessions over 10 weeks and track changes in nocturia, sleep, hot flashes, and mood. The goal is t…

This study compares acupuncture and massage to see which is more effective at reducing pain and improving quality of life in people with advanced cancer. About 300 participants will receive either acupuncture or massage over several weeks. The goal is to find a safe, drug-free wa…

This study tests whether a mindfulness program called MORE can help people with long-term cancer pain. 76 adults with a history of cancer and ongoing pain will either learn mindfulness skills or continue their usual care. The goal is to see if this approach is practical and helpf…

This pilot study tests whether a smartphone app called AmDTx can help lung cancer patients manage anxiety before and after surgery. The app includes mindfulness training and a relaxing puzzle game. Only 6 participants are enrolled, and the main goal is to see if people will actua…

This study trains home-care nurses to deliver a short, meaning-centered psychotherapy to cancer patients who are homebound. The goal is to see if this approach can reduce psychological distress and improve quality of life. The trial involves 81 participants and focuses on trainin…

This study tests whether an interactive 3D tool, used during a standard surgical consultation, helps women feel more satisfied with the information they receive about breast reconstruction options. Researchers will also check if the tool improves satisfaction with their breasts a…

This study tests a 5-week computer-based memory training program for breast cancer survivors who have memory and attention problems after chemotherapy. Sixty women will be randomly assigned to either the full working memory training or a less challenging version. The goal is to s…

This study tests a type of talk therapy called dignity therapy, adapted for sexual and gender minority (LGBTQ+) cancer patients. A trained researcher will interview participants about their lives and create a poem or legacy document they can share with loved ones. The goal is to …

This study looks at how breast cancer treatment affects quality of life in women of different ages. Researchers are asking 650 women recently diagnosed with early-stage breast cancer to fill out questionnaires about their physical and emotional well-being. The goal is to understa…

This study follows 810 young women aged 18-45 with early-stage breast cancer to understand how treatment affects their menstrual cycles and quality of life. Participants complete questionnaires every six months for up to 42 months. The goal is to identify factors that lead to ear…

This study is looking at whether a blood test that measures cell-free DNA (cfDNA) can help doctors know how well first-line treatment is working in people with follicular lymphoma. Researchers will collect blood samples before, during, and after standard treatment, and compare cf…

This study aims to understand why some people who have never smoked develop lung cancer. Researchers are comparing the genes of never-smokers with lung cancer to those without the disease. The goal is to find genetic differences that might increase risk. This is a research study …

This study is creating large registries for non-communicable diseases (like cancer and diabetes) in sub-Saharan Africa. Researchers will collect health data, questionnaires, and biological samples from nearly 7,000 adults, including healthy volunteers for comparison. The goal is …

This study looks at whether watching an educational video about what to expect before and after surgery can help women leave the hospital sooner after a minimally invasive hysterectomy. Researchers will compare patients who watch the video to those who receive usual care. The goa…

This study looks at attention and memory in breast cancer survivors compared to healthy women of the same age. Researchers use EEG to measure brain activity during memory tasks. The goal is to understand why some survivors have trouble focusing or remembering. Results may help de…

This study looks at why some women with breast cancer in one breast later develop cancer in the other breast. Researchers are comparing women with cancer in both breasts to those with cancer in only one breast. They are studying how genes, past radiation treatment, and lifestyle …

This study follows 500 people who had a malignant colorectal polyp removed. Researchers want to learn how often the cancer stays, comes back, or spreads. They will also study how patients and doctors decide on next steps after removal. Participants share medical records and get f…

This study follows 550 people with bladder cancer to understand how treatments like surgery affect their quality of life. Researchers want to learn what patients go through so doctors can offer better support and clearer information. The goal is to improve care, not to test a new…

This study is developing a brief screening tool to identify family members or close friends of patients with advanced cancer who may need professional support while caregiving or after a loss. Researchers will gather feedback from about 52 participants to refine the tool, making …

This study looks at whether combining PET/MRI scans with blood and tumor tissue tests can create a detailed profile of high-grade serous ovarian cancer. The goal is to better predict how tumors respond to treatment, which could help doctors personalize care. The study involves 10…

This study looks at how breast cancer treatment impacts women's jobs, finances, and daily life, especially comparing women from different ethnic groups. About 935 breast cancer survivors who were working before or during treatment will share their experiences. The goal is to unde…

This study is testing a digital health tool to help more people of Ashkenazi Jewish descent get tested for BRCA gene mutations, which increase cancer risk. Over 5,400 participants will use a web portal to learn about testing and decide whether to proceed. The goal is to see if th…

This study explores how cancer patients feel and what they do when they learn about extra genetic findings from their tumor tests. Researchers want to understand how patients decide to share this information with their family members. About 495 adults with solid tumors are taking…

This study aims to develop new tools that use machine learning to evaluate how well surgeons perform robotic surgery. Researchers will collect data from 1,000 surgeons across different specialties as they perform standard procedures. The goal is to find patterns that can help imp…

This study looks at whether it is safe to have an MRI scan when you have breast tissue expanders in place. About 68 people with these expanders will be scanned, and researchers will check for any burning, heating, or pain. The goal is to see if MRI can be done safely in this grou…

This study is testing new ways to perform MRI scans to see if they can produce better images than current methods. About 662 healthy volunteers and patients will undergo MRI scans using both standard and experimental techniques. The goal is to find out whether these new methods i…

This study looks at whether people with HER2-positive breast cancer can safely have fewer heart check-ups while on a specific type of treatment (trastuzumab without anthracyclines). About 190 participants will be followed to see if less monitoring leads to serious heart problems.…

This study looks at how histiocytosis—a group of rare disorders—may affect memory, thinking, and brain structure. Researchers will test 13 adults with these conditions using thinking tasks and MRI scans. The goal is to better understand brain changes, not to provide treatment.…

This study looks at whether a self-administered geriatric assessment can help predict serious side effects in people aged 60 and older with Non-Hodgkin lymphoma who are starting chemotherapy. The goal is to see if this assessment can identify who is at higher risk for hospitaliza…

This study looks at how men with low-risk prostate cancer and their partners or close allies decide on treatment. Researchers want to understand how anxiety and uncertainty influence these choices. About 541 participants will fill out questionnaires about their feelings and prefe…

This study at Memorial Sloan Kettering is developing a secure way to collect dietary information from 150 cancer patients receiving stem cell transplants. Researchers want to see how diet relates to treatment response and gut health. The goal is to build a database that can be us…

This study tests a new computer program that reduces blurring in CT scans used during lung cancer radiation therapy. The goal is to help doctors better locate tumors and track small markers placed in the lungs. About 17 adults with lung cancer who are already scheduled for radiat…

This study tests a digital outreach strategy to help women who are at risk for lung cancer learn about screening. Researchers will contact women ages 50-80 who smoke or recently quit and had a normal mammogram. The goal is to see if emails and a web tool called LungTalk can incre…

This study asks 3000 people who had skin cancer surgery to fill out a one-time online survey about how they feel about their appearance, scars, and quality of life. The goal is to learn what matters most to patients after surgery. No new treatment or medication is being tested.

This study looks at whether hormone therapy (like Lupron or Casodex) changes thinking abilities in men aged 65 and older with prostate cancer. Researchers will compare cognitive function over time between men starting hormone therapy, those who have never had it, and those who ha…

This study analyzes tumor and blood samples from 763 people with bone cancer (osteosarcoma) to understand why some tumors resist chemotherapy. Researchers will test how cancer cells respond to drugs in the lab and look for genetic clues. The goal is to learn more about treatment …

This phase 1 study tests a new PET imaging tracer called 89Zr-cRGDY in 17 people with malignant brain tumors or pituitary adenomas. The tracer is given in a very small dose to see how it spreads and clears from the body. The goal is to improve brain tumor imaging, not to treat th…

This study explores whether ultrasound images analyzed by a special computer program can accurately measure the size of liver tumors in people with pancreatic or gastrointestinal cancer that has spread to the liver. Participants will have both a routine contrast-enhanced CT scan …

This study aims to understand the emotional and practical needs of parents who lost a child to cancer. Researchers will interview 160 parents and use questionnaires to identify themes of grief and meaning. The goal is to use these insights to develop a support program that helps …

This study looks at how small changes in CT scan settings affect measurements of colorectal cancer tumors that have spread to the liver. About 169 adults with these tumors will get an extra CT scan. The goal is to see if tumor measurements stay reliable even when scan details var…

This study follows 219 patients who had liver surgery for colorectal cancer that spread to the liver. Researchers track how patients' quality of life changes over time using surveys. The goal is to help doctors and patients understand what to expect after surgery, so patients can…

This study looks back at 300 patients who had a hip replacement after a cancer-weakened bone broke. Researchers want to see how well patients walk, their pain levels, and how long they live compared to patients from decades ago. The goal is to find what helps people walk again af…

This study follows 600 people with non-muscle invasive bladder cancer to see how changes in smoking habits and body weight after diagnosis affect the chance of cancer coming back. Participants fill out questionnaires and provide saliva or urine samples over time. The goal is to l…

This study looks at whether training Black men who have already completed a colon cancer screening test (FIT) can help encourage three of their peers to also get screened. The goal is to see if this peer outreach approach increases screening rates in the Black community, which ha…

This study examines DNA from over 21,000 cancer patients in New York to find gene changes linked to several cancers, including breast, colon, and lung. Researchers will compare these genes to those from healthy people to spot differences. The goal is to generate ideas for future …

This study aims to create a more accurate way to measure depression in older adults who have or had cancer. Researchers will interview patients and test a new questionnaire designed specifically for this group. The goal is to improve how doctors identify and treat depression in o…

This study looks at how diet, lifestyle, and genetics influence the risk of endometrial cancer. Researchers will compare women who have or had the cancer with those who do not, using surveys and genetic analysis. The goal is to identify factors that may increase or decrease risk,…

This study aims to find out how common persistent pain is after mastectomy and breast reconstruction, and whether a nerve surgery called RPNI can help reduce that pain. Researchers will follow 274 women who had mastectomy and reconstruction at Memorial Sloan Kettering. The study …

This pilot study is looking at whether dental erosion (loss of tooth enamel) could be a non-invasive biomarker for esophagogastric cancer and other cancers. Researchers will survey 174 participants (cancer patients and healthy volunteers) about diet, habits, and GERD symptoms, an…

This study looks at whether it is practical to give women recovering from breast-conserving surgery or mastectomy with reconstruction immediate feedback from their recovery surveys. The tool, called BREAST-Q REACT, shows scores on physical well-being and arm function and offers t…

This study looks at how doctors, patients with glioblastoma (a serious brain cancer), and their caregivers talk about the disease, scan results, and treatment choices. Researchers will use surveys and tests to understand these conversations. The goal is to find ways to improve co…

This study is testing a new set of evaluations called the SAE (Sensory-Attention-Executive) Battery to see if it can help researchers learn how breast cancer treatment affects the brain. Researchers will compare results from the SAE Battery with traditional questionnaires in 187 …

This study aims to create better guidelines for reading PET scans in people with neuroendocrine tumors. Researchers will compare new criteria against the current standard to see which better predicts if a tumor shrinks, grows, or stays the same. The study involves 11 participants…

This study collects tissue, blood, and other fluid samples from men with prostate conditions, including those with no cancer, localized disease, or advanced stages. Researchers will analyze genetic changes and protein markers to understand why some men get prostate cancer, why so…

This study looks at how often cancer patients with risk factors like age, diabetes, or smoking have peripheral arterial disease (PAD), a condition where blood vessels narrow. Researchers will test 114 patients before surgery using simple ankle and toe blood pressure measurements.…

This study uses three advanced MRI techniques to see if they can predict how well head and neck cancer patients will respond to surgery or chemo-radiation. About 272 adults with head and neck cancer will get these scans before and early during treatment. The goal is to find marke…

This study tests a communication training program for nurses and social workers at Memorial Sloan Kettering Cancer Center. The goal is to help them respond more effectively and compassionately to the challenges faced by families caring for a hospitalized cancer patient. About 80 …

This study looks at how different antibiotics change the friendly bacteria in the gut of people who have had a stem cell transplant and develop a fever with low white blood cells. The goal is to understand which antibiotics are gentler on these helpful bacteria, which may lead to…

This study looks at whether a sentinel lymph node biopsy (a less invasive procedure) can accurately find leftover cancer cells after chemotherapy in women with locally advanced breast cancer. Researchers will compare the biopsy results to the standard full lymph node removal. The…

This study looks at how surviving cancer as a teen or young adult affects a person's identity, friendships, and family life. Researchers will interview and hold group discussions with 300 survivors aged 15 to 25 who finished treatment at least 6 months ago. The goal is to learn w…

This study looks at people with advanced ovarian cancer who have a second look laparoscopy after finishing their first chemotherapy. Doctors want to compare health outcomes between those who still have small amounts of cancer left and those who don't. They also want to see if thi…

This study looks at how proton beam radiation affects brain networks and thinking in children and young adults (ages 6-25) treated for brain tumors. Researchers will use special MRI scans taken at rest, along with thinking tests and quality-of-life questionnaires, to compare pati…

This study is testing a special imaging agent called [13C]pyruvate to see how it behaves in healthy organs and tissues during MRI scans. Fifty healthy volunteers aged 18 to 80 will receive an injection of the agent, and researchers will measure image quality. The goal is to impro…

This study follows 338 people who have two or more ground glass opacities (GGOs) in their lungs—small, hazy spots seen on CT scans. Instead of treating them right away, doctors will monitor them over time to learn more about how these spots behave and whether they lead to lung ca…

This study observes 49 patients with relapsed or refractory multiple myeloma and their doctors to find out why some patients don't receive advanced cell therapies like CAR T-cells or stem cell transplants. Researchers will track referral rates and use questionnaires to measure an…

This study looks at how the drug tucatinib enters and works in HER2+ cancers that have spread to the brain. Nine adults with breast, lung, or other cancers will take tucatinib before brain surgery. Researchers will test tumor samples to find genetic clues about why some cancers s…

This study looks at how certain gene changes may increase cancer risk. Researchers collect DNA and medical information from people with these gene changes and their family members. The goal is to give doctors better information to help families understand their cancer risks.

This study looks at conversations between lung cancer patients and their healthcare providers. Researchers want to learn how these talks affect patient well-being and satisfaction. About 294 patients will take part, sharing their experiences through interviews and questionnaires.…

This study looks at how bacteria living in the gut and diet might influence colorectal cancer risk in people with Lynch syndrome and other inherited colon conditions. Researchers will collect stool samples, colon biopsies, and diet questionnaires from 77 participants during routi…

This study looks at how chemotherapy and other factors affect thinking and memory in older women who survived breast cancer. Researchers will compare these women to older women who never had cancer. They will also study how genetics and smoking history play a role. About 500 wome…

This study looks at how regular exercise might change the biology of breast tumors in women with early-stage breast cancer. Researchers will compare tumor and normal tissue samples from 42 women who exercise regularly versus those who don't. The goal is to understand if exercise …

This study looks at how safe and doable different amounts of aerobic exercise are for people about to have surgery for solid tumors like breast, endometrial, or prostate cancer. About 60 participants will exercise at home while using apps and devices to track their activity. The …

This study looks at the long-term health and quality of life of adults who had retinoblastoma, a rare eye cancer, as children. Researchers want to understand how survivors are doing physically and emotionally, and what challenges they face. The goal is to improve care and follow-…

This study looks at how prostate cancer changes after radiation treatment using special MRI scans. Researchers want to see if these scans can help doctors manage treatment better and sooner. About 120 men with prostate cancer who are getting radiation will take part.

This study looks at whether training doctors in communication skills can help lymphoma patients move from active treatment to survivorship. It involves 314 patients with Hodgkin's or Diffuse Large B-cell Lymphoma. The goal is to see if better conversations with their doctors impr…

This early-phase study tests a radioactive imaging drug called 124I-PUH71 in 63 people with non-Hodgkin's lymphoma, myeloma, or solid tumors. The goal is to see how the drug travels through the body and collects in tumors, and how long it stays in the blood. This is not a treatme…

This study collects leftover tissue, blood, and other fluid samples from 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples in lab studies to better understand the causes, prevention, diagnosis, …

This study gathers information from cancer patients and their household members to better understand COVID-19 infections. Participants fill out online questionnaires about their health and lifestyle. The goal is to create a registry that helps researchers see how COVID-19 affects…

This study looks at whether giving smokers information about how smoking affects their teeth and gums can help them quit. Over 1,000 people who smoke at least 10 cigarettes a day and visit a dental clinic took part. Researchers want to find new ways to support quitting by using d…

This study collects blood and saliva samples from people with cancer and their relatives to build a DNA bank. Researchers hope to better understand how cancer runs in families. About 992 participants are expected to join. The samples will be stored and analyzed later for genetic …

This study collects blood, tissue, and saliva samples from 7,000 people—both those with breast cancer and healthy volunteers. Researchers at Memorial Sloan Kettering will use these samples to study what causes breast cancer and find better ways to prevent, detect, and treat it. N…

This study looks at whether people with Lynch Syndrome—a condition that raises the risk for several cancers—follow recommended screening guidelines after genetic counseling. Researchers will track about 1,530 participants to see who gets the suggested tests and what factors help …

This study involves 230 adults with cancer that has spread to their bones who need surgery. Researchers want to improve how doctors estimate survival by combining the patient's own health assessment with the doctor's evaluation. The goal is to create a more accurate prediction to…

This study looks at tissue from liver tumors that were destroyed using heat or cold (ablation). The goal is to see if a special test on that tissue can tell whether the treatment fully killed the cancer, which standard CT scans cannot always do. About 150 people with liver cancer…

This study creates a registry for people with BRCA or PALB2 gene mutations who have pancreatic cancer, along with their close relatives. Researchers will collect medical information, blood samples, and tumor tissue to better understand why pancreatic cancer develops in this group…

This study trains 350 cancer care providers in Meaning-Centered Psychotherapy, a method to help patients find meaning and cope with cancer. Providers attend a two-day workshop, followed by calls and webinars, and are assessed on their skills for one year. The goal is to improve h…

This study looks at how normal breast tissue appears on MRI and mammogram to see if it can help predict breast cancer risk. Researchers are comparing images and health information from over 2,000 women, including those with and without breast cancer. The goal is to better underst…

This pilot study is testing a radioactive antibody called 124I-Humanized 3F8 to see how it travels through the body and attaches to tumors in people with melanoma, neuroblastoma, or sarcoma. Seven participants will receive the antibody and then have PET/CT scans at several time p…

This pilot study aims to develop new ways to diagnose colon cancer and predict if it will spread to the liver. Researchers will collect blood and liver tissue samples from 51 patients undergoing surgery for colon cancer or benign colon growths. The goal is to find biomarkers that…

This study follows 546 women with non-metastatic breast cancer to see how chemotherapy or endocrine therapy affects their hair, skin, and nails. Researchers will use clinical exams, photos, and questionnaires to track changes and identify who is most at risk. The goal is to bette…

This study looks at whether a set of online, game-like tests can reliably measure changes in thinking and memory in breast cancer survivors. About 441 women aged 40-65 will take these tests from home. The goal is to find a better way to detect and understand cognitive problems af…

This pilot study looks at how the chemotherapy drug cisplatin affects the inner lining of blood vessels (the endothelium) in men with germ cell tumors. Researchers will measure blood vessel function in patients receiving cisplatin and compare them to a group who had surgery only.…

This study searches for new gene changes (mutations) that appear in cancer patients but not in their healthy parents. By comparing DNA from 1,275 people with certain cancers and their families, researchers hope to find genetic clues that increase cancer risk. The goal is to bette…

This study looks at whether a blood test can spot signs of lymphoma coming back after chemotherapy, possibly earlier than regular CT scans. About 500 adults with aggressive B-cell Non-Hodgkin lymphoma will give blood samples after treatment. The goal is to see if this test could …

This study looks back at the medical records of 250 sarcoma patients treated with immunotherapy at Memorial Sloan Kettering Cancer Center. The goal is to learn more about how well these treatments work and how they are used. No new treatments are given—researchers simply collect …

This study looks at whether adding a breath-holding task to standard brain scans can make mapping of important brain areas more accurate in people with brain tumors. About 33 patients and healthy volunteers will have functional MRI scans while doing language tasks, with and witho…

This study follows 26 adults with small basal cell carcinomas (a common skin cancer) for up to 3 years. Researchers use special cameras and scans to measure how the cancers change in size and depth. The goal is to learn more about tumor growth and find better ways to monitor thes…

This study looks at how prostate cancer survivors' thinking and memory (called cognitive function) may be linked to other health issues like anxiety, depression, and trouble sleeping. Researchers will also examine how social factors, cancer details, and treatments might play a ro…

This study looks at a simpler way to offer genetic testing to people with ovarian, prostate, or pancreas cancer. Instead of always sending patients to a genetic counselor, doctors and surgeons would offer the test directly, and counselors would share results by phone. Researchers…

This study looks at how well a cardiopulmonary exercise test (CPET) can measure oxygen use in women with HER2-positive breast cancer who have mild heart problems from their cancer treatment. The goal is to see if this test can help predict how their heart and lungs will handle co…

This study tests a training program called PACT that teaches nurses how to better support families of patients with advanced gastrointestinal cancer. About 84 nurses and family caregivers at Memorial Sloan Kettering will take part. The goal is to see if the training helps nurses …

This study looks at how surviving a pediatric brain tumor affects thinking and behavior. Researchers will use brain scans to examine brain structure in children who have completed treatment. The goal is to better understand the long-term cognitive challenges these survivors may f…

This study creates a large registry of people with and without urothelial cancer (bladder, ureter, or renal pelvis cancer) to learn how genes and lifestyle affect risk. Participants provide a saliva sample and fill out questionnaires. The goal is to improve prevention, diagnosis,…

This study looks at children and teens who survived retinoblastoma in one eye. Researchers want to see if those who had chemotherapy injected into the eye artery have a different quality of life than those who had the eye removed. Participants and their parents will fill out surv…