Can nerve surgery ease pain after mastectomy? new study investigates

NCT ID NCT06627582

Ongoing Knowledge-focused Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to find out how common persistent pain is after mastectomy and breast reconstruction, and whether a nerve surgery called RPNI can help reduce that pain. Researchers will follow 274 women who had mastectomy and reconstruction at Memorial Sloan Kettering. The study uses questionnaires to measure pain and will test the nerve surgery in some participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: regenerative peripheral nerve interface (RPNI) surgery
What this could lead to: If successful, this could point toward a surgical option to reduce long-term nerve pain after breast reconstruction.
What could go wrong: This is an observational study with a small surgical component, so it cannot prove that RPNI surgery works. The results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST RECONSTRUCTION BREAST RECONSTRUCTION AFTER MASTECTOMY MASTECTOMY MASTECTOMY AND BREAST RECONSTRUCTION MASTECTOMY PATIENT POSTMASTECTOMY PAIN

Contacts and locations

Locations

Memoral Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920, United States
Memoral Sloan Kettering Monmouth (Limited protocol activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All protocol activites)

New York, New York, 10065, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activites)

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity)

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York, 10604, United States

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