BREAST RECONSTRUCTION

This study follows 650 women aged 18 to 65 who receive Eurosilicone LunaXT silicone breast implants for cosmetic augmentation or reconstruction after mastectomy. Researchers track how often the implants rupture or cause severe capsular contracture (hardening of scar tissue) over …

This phase 3 trial tests whether a shorter, higher-dose radiation schedule (3 weeks) is as safe and effective as the standard 5-week schedule for women with high-risk breast cancer who have had a mastectomy and immediate implant reconstruction. The study will enroll 506 women and…

This study tests a device called ARTIA, a special tissue matrix used during implant-based breast reconstruction after mastectomy. About 264 adults who need immediate reconstruction will receive ARTIA to see if it reduces major complications like infection or implant failure. The …

This study is testing a device called OviTex PRS, made from sheep stomach tissue and polymer thread, for women having breast reconstruction after mastectomy. The goal is to see if it is safe and effective at reducing complications like reconstructive failure. About 235 women will…

This study tests whether using a pressurized, pulsed antibiotic wash during breast reconstruction surgery reduces complications like infection, bleeding, fluid buildup, or implant failure. Researchers will compare this method to the standard wash using a bulb syringe. The trial e…

This study tests whether hyperbaric oxygen therapy (HBOT) can help transplanted fat survive longer in breast reconstruction after radiation treatment. Sixteen women who had radiation for breast cancer will each receive two fat grafting sessions—one with HBOT and one without—in a …

This study tests a special material (acellular dermal matrix) used in a two-stage breast reconstruction procedure for women who have had a mastectomy. The goal is to see if it reduces complications like infections or the need for extra surgeries, and improves quality of life. Abo…

This study looks at a new material called SC DERM® Recon, used in breast reconstruction surgery after mastectomy for breast cancer. Researchers want to see if it causes fewer short-term problems than similar materials. About 120 women will take part, and the study will track comp…

This study is testing whether combining fat grafting with a muscle flap from the back can improve delayed breast reconstruction after mastectomy. Twenty women who had a nipple-sparing mastectomy will receive the procedure. The main goal is to see if it reduces wound infections or…

This study tests a special absorbable mesh that releases antibiotics to help prevent infections in women undergoing two-stage breast reconstruction after mastectomy. About 702 women will be randomly assigned to receive either standard care or the new mesh. The goal is to see if t…

This study compares three devices used for fat grafting in breast reconstruction after mastectomy. Researchers want to see which method leads to better fat retention and patient satisfaction. About 135 women who have had breast surgery will take part, and their results will be me…

This study compares two ways to perform nipple-sparing mastectomy with immediate DIEP flap breast reconstruction: robotic-assisted surgery through a single small incision, versus the standard open surgery with a larger cut. The goal is to see which approach leads to better patien…

This study tests whether applying minoxidil (a hair growth drug) to the breasts for two weeks before surgery can improve blood flow and tissue survival in women undergoing preventive mastectomy with reconstruction. Twenty-five women at high genetic risk for breast cancer will hav…

This study compares two types of nerve blocks—paravertebral and pectoral—given before implant-based breast reconstruction surgery. Researchers will measure pain levels and physical well-being in 212 adult patients. The goal is to find which block offers better recovery and comfor…

This study tests whether a short educational video about safe opioid use can help breast reconstruction patients use fewer painkillers after surgery. About 68 women will be randomly assigned to watch the video or receive standard care. Researchers will track how many opioids they…

This study follows 60 women aged 18 to 65 who receive Nagor PERLE silicone breast implants for breast reconstruction, augmentation, or revision surgery. Researchers will monitor complications like capsular contracture (hardening) and implant rupture over 10 years. The goal is to …

This study is testing a portable device that measures electrical signals and light absorption to monitor blood flow in tissue flaps used for breast reconstruction. Ten women undergoing this surgery will have the device attached to the flap during the operation. The goal is to see…