Immune cell boost after transplant shows promise for tough lymphoma

NCT ID NCT01840566

First seen Jan 04, 2026 · Last updated May 07, 2026 · Updated 18 times

Summary

This early-phase study tested whether giving patients their own genetically modified immune cells (CAR T-cells) after high-dose chemotherapy and a stem cell transplant is safe for treating aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. Seventeen adults with relapsed or refractory disease took part. The goal was to find the safest dose of these cells and monitor side effects, while also tracking how long the cancer stays away and overall survival.

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Contacts and locations

Locations

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack (Limited protocol activities)

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth (Limited protocol activities)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau (Limited protocol activites)

    Rockville Centre, New York, 11553, United States

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison, New York, 10604, United States

  • Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jersey, 07920, United States

Conditions

Explore the condition pages connected to this study.