Diet and diabetes drug may boost breast cancer therapy

NCT ID NCT05090358

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether a very low-carb (ketogenic) diet, a low-carb diet, or the diabetes drug canagliflozin can prevent high blood sugar and possibly make standard cancer therapy more effective. It involves 15 people with advanced, hormone-receptor-positive breast cancer that has a specific gene mutation (PIK3CA). The goal is to improve how well the cancer drugs alpelisib and fulvestrant work.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Suffolk - Commack (Limited protocol activity)

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Westchester (All protocol Activities)

    Harrison, New York, 10604, United States

  • Ohio State University (Data Collection & Data Analysis)

    Columbus, Ohio, 43210, United States

  • Weill Cornell Medical College (Data Collection & Data Analysis)

    New York, New York, 10065, United States