Engineered t cells take on chest cancer in new trial
NCT ID NCT02414269
First seen Jun 24, 2026 · Last updated Jul 23, 2026 · Updated 4 times
Summary
This study tests a treatment using a patient's own immune cells (T cells) that are genetically modified to recognize and attack a protein called mesothelin found on cancer cells. The treatment is given through a tube in the chest to people with malignant pleural disease, including mesothelioma and lung or breast cancer that has spread to the chest lining. The first phase checks safety and dosing, while the second phase adds the drug pembrolizumab to see if the combination works better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- genetically modified T cells (iCasp9M28z) and pembrolizumab
- What this could lead to
- If successful, this could offer a new treatment option for malignant pleural disease, including mesothelioma, by harnessing the immune system to attack cancer cells.
- What could go wrong
- This is an early-phase trial (phase I/II) with a small number of participants, so safety and effectiveness are not yet proven. There are risks of side effects from the modified T cells and pembrolizumab, such as infusion reactions or immune-related inflammation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Memorial Sloan Kettering Basking Ridge (Consent and Follow-Up)
Basking Ridge, New Jersey, United States
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Memorial Sloan Kettering Bergen (Consent and Follow-Up)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (Consent and Follow-Up)
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack (Consent and Follow-Up)
Commack, New York, United States
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Memorial Sloan Kettering Monmouth (Consent and Follow-Up)
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Westchester (Consent and Follow-Up)
Harrison, New York, 10604, United States
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