Ultrasound may spare breast cancer patients from unnecessary surgery
NCT ID NCT04854005
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether using ultrasound before surgery can help identify women with early-stage HR+/HER2- breast cancer who have only a few affected lymph nodes. If so, they may be able to have a less invasive sentinel lymph node biopsy instead of a more extensive axillary lymph node dissection. The goal is to reduce side effects like arm swelling while still effectively treating the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Breast surgery (sentinel lymph node biopsy)
What this could lead to
If successful, this approach could help many women with early-stage HR+/HER2- breast cancer avoid the more invasive axillary lymph node dissection and its side effects.
What could go wrong
This is a small, early-stage study with only 78 participants. It may not prove that avoiding ALND is safe for all patients, and some may still need the more extensive surgery.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hartford Healthcare Cancer Alliance (Data collection only)
Hartford, Connecticut, 06102, United States
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Lehigh Valley Health Network (Dara Collection Only)
Allentown, Pennsylvania, 18103, United States
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Memorial Sloan Kettering Basking Ridge (Consent Only)
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen (Consent Only)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (Consent Only)
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Suffolk - Commack (Consent Only)
Commack, New York, 11725, United States
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Memorial Sloan Kettering Westchester (Consent Only)
Harrison, New York, 10604, United States
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University of Michigan (Data Collection Only)
Ann Arbor, Michigan, 48109, United States