Could walking and a Plant-Based diet help tame breast cancer?

NCT ID NCT04298086

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial investigates whether a program of regular walking and a plant-based diet can lower aromatase levels in overweight postmenopausal women with hormone receptor-positive breast cancer who are already taking an aromatase inhibitor. Participants are randomly assigned to receive either the exercise and diet intervention or standard care. The study also looks at changes in breast tissue gene expression and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exercise and plant-based diet
What this could lead to: If successful, this could show that lifestyle changes help control hormone levels and improve quality of life for breast cancer survivors.
What could go wrong: This is a small, early-phase trial (43 participants) and may not prove that diet and exercise directly affect cancer outcomes. Results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer Obesity Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER PRIMARY HORMONE RECEPTOR POSITIVE BREAST CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (Limited Protocol Activities)

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York, 10604, United States

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