Could a sweat session rewrite breast cancer risk?

NCT ID NCT02494869

Ongoing Prevention Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study tests whether different amounts of progressive aerobic exercise can reduce risk factors for breast cancer in women who are at high risk. Participants will follow an exercise program, and researchers will measure changes in exercise capacity, body composition, and gene activity in breast tissue. The goal is to see if exercise can positively influence biological markers linked to cancer development.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nonlinear aerobic training (a progressive exercise program)
What this could lead to: If exercise dose affects breast cancer risk factors, this could lead to tailored exercise prescriptions for prevention in high-risk women.
What could go wrong: The study is early and small, and results may not apply to all women. Exercise may not change risk factors as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lobular breast carcinoma in situ Motor Activity breast cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH RISK FOR DEVELOPING BREAST CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

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