Can a drug shrink precancerous breast cells before surgery?
NCT ID NCT02928978
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a drug called ruxolitinib can reduce abnormal breast cells in people with high-risk or precancerous breast conditions like DCIS or atypical hyperplasia. Half of the 84 participants took ruxolitinib for about 15 days before surgery, and the other half took a placebo. Researchers compared cell death in breast tissue samples taken before and after treatment to see if the drug had an effect.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Harris Health System - Smith Clinic
Houston, Texas, 77054, United States
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Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202, United States
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Montefiore Medical Center
The Bronx, New York, 10461, United States
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O'Quinn Medical Tower - McNair Campus; Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77054, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States