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Could a 'Baby Dose' of hormone pills prevent breast cancer?

NCT ID NCT07499999

Not yet recruiting Prevention Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether low doses of two hormone-blocking drugs, exemestane and tamoxifen, can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year, and researchers will measure side effects and quality of life. The goal is to find a prevention option with fewer side effects than standard doses.

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Conditions

The condition(s) this trial relates to.

atypical lobular breast hyperplasia BRCA2-related cancer predisposition breast ductal adenocarcinoma breast intraductal proliferative lesion breast neoplasm Carcinoma, Ductal CHEK2-related cancer predisposition ductal breast carcinoma in situ estrogen-receptor positive breast cancer lobular breast carcinoma in situ breast cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATAXIA TELANGIECTASIA MUTATED GENE MUTATION ATYPICAL LOBULAR HYPERPLASIA BRCA2 MUTATION BREAST CANCER CHEK2 GENE MUTATION DUCTAL CARCINOMA ESTROGEN RECEPTOR-POSITIVE BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••