Double-Dose CAR t strategy aims to outsmart relapsed leukemia
NCT ID NCT05460533
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 26 times
Summary
This study tests whether giving a second, early infusion of the CAR T-cell therapy tisagenlecleucel can keep the immune system's B cells suppressed for at least 6 months in children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. About 30 participants who already received one dose and have extra cells available will get an early reinfusion. The goal is to reduce the rate of losing B-cell aplasia from 26% to below 10%, which may help prevent the cancer from coming back.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Children's Hospital Colorado (Data Collection Only)
Aurora, Colorado, 80045, United States
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Children's Hospital of Los Angeles (Data Collection Only)
Los Angeles, California, 90027, United States
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Cincinnati Children's Hospital Medical Center (Data Collection Only)
Cincinnati, Ohio, 45229, United States
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Johns Hopkins University (Data Collection Only)
Baltimore, Maryland, 21287, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Stanford University (Data Collection Only)
Stanford, California, 94305, United States
Conditions
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