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Targeted drug aims to clear hidden leukemia before transplant

NCT ID NCT03610438

Ongoing Disease control Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests whether the targeted drug inotuzumab ozogamicin can eliminate minimal residual disease (MRD) in adults with B-cell acute lymphoblastic leukemia (ALL) before they receive a stem cell transplant. Participants have either Philadelphia chromosome-positive or -negative ALL with detectable MRD after prior therapy. The goal is to see if the drug can make MRD undetectable, which may lead to better transplant outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
inotuzumab ozogamicin, an antibody-drug conjugate that targets cancer cells
What this could lead to
If successful, this approach could help more patients achieve a cancer-free state before a stem cell transplant, potentially improving long-term outcomes.
What could go wrong
This is an early-phase study with a small number of participants, so results may not apply broadly. The drug can cause serious side effects like liver damage and low blood cell counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOID LEUKEMIA

Contacts and locations

Locations

  • Ao Di Rilievo Nazionale Antonio Cardarelli - Napoli - Uoc Ematologia Con Trapianto Di Midollo

    Naples, Italy

  • Ao Ospedali Riuniti Villa Sofia Cervello - Palermo - Uo Ematologia Con Utmo

    Palermo, Italy

  • Aou "San Giovanni Di Dio E Ruggi D'Aragona" - Salerno - Uoc Ematologia E Trapianti Di Cellule Staminali Emopoietiche

    Salerno, Italy

  • Aou Città Della Salute E Della Scienza, Ospedale S. Giovanni Battista Molinette - Torino - Sc Ematologia 2

    Torino, Italy

  • Aou Di Bologna - Policlinico S. Orsola-Malpighi - Uoc Ematologia

    Bologna, Italy

  • Aou Integrata Di Verona, Policlinico G.B. Rossi - Uoc Ematologia

    Verona, Italy

  • Aou Ospedali Riuniti "Umberto I - G.M. Lancisi - G. Salesi"- Ancona- Sod Clinica Ematologica

    Ancona, Italy

  • Aou Senese - Uoc Ematologia E Trapianti

    Siena, Italy

  • Area Vasta N. 5 Ascoli Piceno - S. Benedetto Del Tronto, Presidio Ospedaliero Av5 Osp. Gen. Prov.Le "C.G.Mazzoni" - Uoc Ematologia

    Ascoli Piceno, Italy

  • As Dell'Alto Adige, Ospedale Centrale Di Bolzano - Ematologia E Centro Trapianto Midollo Osseo

    Bolzano, Italy

  • Asl Lecce, Ospedale 'V. Fazzi' - Uo Ematologia

    Lecce, Italy

  • Asl Pescara, Presidio Ospedaliero 'Spirito Santo' - Uoc Ematologia Clinica

    Pescara, Italy

  • Asl Roma 2, Ospedale S. Eugenio- Ospedale S.Eugenio - Uoc Ematologia

    Roma, Italy

  • Aso S. Croce E Carle - Cuneo - Sc Ematologia

    Cuneo, Italy

  • Asst Degli Spedali Civili Di Brescia - Uo Ematologia

    Brescia, Italy

  • Asst Grande Ospedale Metropolitano Niguarda - Milano - Sc Ematologia

    Milan, Italy

  • Asst Papa Giovanni Xxiii - Ospedale Di Bergamo - Sc Ematologia

    Bergamo, Italy

  • Asui Di Udine - Presidio Ospedaliero "Santa Maria Della Misericordia" - Clinica Ematologica

    Udine, Italy

  • Aulss 3 Serenissima, Ospedale Dell'Angelo - Mestre - Uo Ematologia

    Mestre, Italy

  • Aulss 8 Berica - Ospedale Di Vicenza - Uoc Ematologia

    Vicenza, Italy

  • Ausl Della Romagna, Ospedale "Infermi" - Rimini - Uo Ematologia

    Rimini, Italy

  • Ente Ecclesiastico Casa Sollievo Della Sofferenza - San Giovanni Rotondo - Ematologia

    San Giovanni Rotondo, Italy

  • Fondazione Ircss Policlinico San Matteo - Pavia - Uo Ematologia

    Pavia, Italy

  • Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli" Po E. Morelli - Reggio Calabria - Uoc Ematologia

    Reggio Calabria, Italy

  • I.R.S.T. Srl Irccs - Meldola - Sc Oncologia Medica

    Meldola, Italy

  • Irccs Aou San Martino - Genova - Uo Clinica Ematologica

    Genova, Italy

  • Irccs Ospedale S. Raffaele - Milano - Uo Oncoematologia

    Milan, Italy

  • Istituto Europeo Di Oncologia Irccs - Milano - Divisione Di Oncoematologia

    Milan, Italy

  • Unità Operativa Di Ematologia - Presidio Ospedaliero Di Treviso - Azienda Ulss N.2 Marca Trevigiana

    Treviso, Italy

  • Università Degli Studi Di Roma "Sapienza" - Dipartimento Di Medicina Traslazionale E Di Precisione - U.O.C. Ematologia

    Roma, Italy

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