Fighting fat to fight leukemia: could a diet and exercise plan boost chemo?
NCT ID NCT05082519
First seen Aug 19, 2026 · Last updated Aug 19, 2026
Summary
This trial tests whether a personalized diet and exercise plan during the first month of chemotherapy can make leukemia cells more sensitive to treatment in older children, adolescents, and young adults with B-cell acute lymphoblastic leukemia (B-ALL). The study also aims to reduce the body fat gain that often occurs during chemo, which is linked to drug resistance. Participants are randomly assigned to either receive the diet and exercise intervention alongside standard chemo or standard chemo alone. The goal is to see if this approach can lower the chance of leftover leukemia cells after induction therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A personalized diet and exercise program (caloric restriction and physical activity)
- What this could lead to
- If effective, this approach could make chemotherapy more powerful against leukemia and reduce treatment-related weight gain, potentially improving outcomes for young patients.
- What could go wrong
- This is an early-phase trial, and the diet/exercise plan may be hard to follow or may not meaningfully change chemotherapy response. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Baylor Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
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C.S. Mott University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Children's Healthcare of Atlanta at Egleston
NOT_YET_RECRUITINGAtlanta, Georgia, 30322, United States
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital Orange County
RECRUITINGOrange, California, 92868, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Hospitals and Clinics of Minnesota
RECRUITINGMinneapolis, Minnesota, 55404, United States
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Children's Mercy Hospital
RECRUITINGKansas City, Kansas, 64108, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Colorado Children's Hospital
RECRUITINGDenver, Colorado, 80045, United States
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Levine Children's Hospital
RECRUITINGCharlotte, North Carolina, 28203, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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UCSF School of Medicine
RECRUITINGSan Francisco, California, 94158, United States
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University of Texas, Southwestern
RECRUITINGDallas, Texas, 75235, United States
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