Can a new combo drug tame childhood leukemia that Won't quit?
NCT ID NCT07770698
First seen Aug 18, 2026 · Last updated Aug 18, 2026
Summary
This trial is investigating whether a new drug called sonrotoclax, when combined with other anti-cancer medicines, is safe and effective for children and adolescents with acute myeloid leukemia (AML) or B-cell acute lymphoblastic leukemia (ALL) that has returned or not responded to treatment. The study will test different doses to find the best one and will monitor how the body processes the drug. The goal is to see if the combination can reduce or eliminate leukemia cells.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sonrotoclax (BGB-11417) combined with azacitidine, inotuzumab ozogamicin, and dexamethasone
- What this could lead to
- If successful, this combination could offer a new treatment option for children with hard-to-treat leukemias, potentially improving remission rates.
- What could go wrong
- This is an early-phase trial with a small number of participants, so safety and effectiveness are not yet established. The drug combination may cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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