PEDIATRIC ALL

This is a first-in-human study to test the safety and find the right dose of a new type of CAR T-cell therapy for children and young adults (up to age 21) whose CD19-positive leukemia has come back or hasn't responded to other treatments. The therapy uses immune cells (T-cells) f…

This study is checking if a fish oil-based IV nutrition product called Omegaven is safe for long-term use in children with liver damage caused by standard IV nutrition. It will follow 40 children under 18 who need this treatment for more than 8 weeks. The main goal is to see if t…

This study is testing if a special home exercise bike that connects to a video game is a safe and practical way to help children who have had a heart transplant get stronger. Researchers want to see if this 12-week program can improve the kids' fitness, activity levels, and quali…

This study aims to figure out which parts of therapy work best to help children and teenagers recover from post-traumatic stress disorder (PTSD). Researchers will test different combinations of therapy techniques with 200 young participants who have experienced trauma. The goal i…

This study aims to monitor the long-term safety and effectiveness of Miltenyi's CAR T cell therapies in patients who were treated at least a year ago. It will follow 40 patients with various cancers, including lymphoma, leukemia, and melanoma, to check for any late side effects a…

This study is testing a home exercise program that uses a special video game-linked exercise bike to help young people with congenital heart disease get fitter. Researchers want to see if this fun, supervised 8-week program improves exercise ability, physical activity levels, and…

This study is testing whether a simple brainwave (EEG) reading can help doctors predict which children will need a higher dose of sedation medicine to successfully complete a brain MRI scan. It involves children aged 1 to 5 years, or older children who may have trouble staying st…

This study is testing a computer tool called pediatric eCART that uses a child's health records to quickly calculate their risk of getting much sicker in the hospital. It will compare outcomes for 30,000 children before and after the tool is introduced to see if it helps doctors …

This study aims to create a new, easier-to-use tool for detecting early signs of movement problems in babies. Researchers will use special sensors and video recordings of babies' movements, combined with artificial intelligence (AI), to see if they can accurately predict future m…

This study is testing if a drug called sugammadex helps children wake up more calmly after eye muscle surgery. It compares sugammadex to the standard drug, neostigmine, which are both given to reverse muscle relaxants used during anesthesia. The goal is to see if sugammadex leads…

This study aims to find out if pulse oximeters—the clip-on devices that measure oxygen levels—are equally accurate for children of all skin colors. Researchers will observe 650 children under 18 who are already having a heart procedure, comparing the pulse oximeter reading to a m…

This study looks back at existing medical records, brain scans, and genetic data from children and young adults up to age 20. The goal is to develop better computer models that can help doctors understand and predict developmental disorders. It involves analyzing information from…

This study aims to better understand how children's bodies process and eliminate standard leukemia drugs. Researchers will observe 200 children under 21 who are already receiving these medications as part of their normal care. The goal is to gather detailed information on drug le…

This study aims to track the long-term safety and performance of orthopedic implants in children. It will follow 4000 young patients who receive devices for conditions like fractures, limb deformities, or hip problems. The goal is to collect real-world data on how well the implan…

This study aims to collect normal walking and movement data from healthy children and teenagers. Researchers will measure how 40 participants, aged 3 to 25, walk and move using special cameras and floor sensors. This 'normal' data will be used as a comparison to help doctors bett…