PEDIATRIC ALL

This early-stage trial tests a new type of cell therapy for children and young adults up to age 21 with a form of leukemia (CD19-positive) that has returned or not responded to treatment. The therapy uses immune cells from a family donor that are engineered in a lab to recognize …

This study follows 40 people who received Miltenyi CAR T cell therapy at least one year ago for cancers like melanoma, lymphoma, or leukemia. Researchers will track side effects, cancer return, and overall health for years. The goal is to understand the long-term safety and effec…

This study is testing the safety of Omegaven, a fish oil-based fat emulsion, in 40 children under 18 who have developed liver problems (cholestasis) from long-term IV nutrition. The main goal is to see how many children develop essential fatty acid deficiency during at least 8 we…

This study looks at whether a special brain wave monitor (EEG) can help doctors choose the right amount of sedation medicine for children who need a brain MRI. About 50 children under 5 years old (or older children who have trouble staying still) will receive a standard low dose …

This study looks at whether a computer program called pediatric eCART can help doctors quickly identify children in the hospital who are at high risk of serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put into use, …

This study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …

This study aims to find out which parts of behavioral therapy work best for children aged 8-17 with PTSD after a traumatic event. Researchers will compare different therapy components, like emotion regulation and exposure, to a placebo. 200 children and their caregivers will part…

This study tests whether a special exercise bike that connects to video games can help children aged 10-18 who have had a heart transplant get more fit. Ten kids will use the MedBIKE at home for 12 weeks, doing short bursts of intense exercise. The main goal is to see if the prog…

This study tests whether giving sugammadex (a drug that reverses muscle relaxants) can lower the chance of children waking up agitated after strabismus (eye muscle) surgery. About 76 children aged 4 to 7 will be randomly assigned to receive either sugammadex or a standard drug (n…

This trial tests a home-based exercise bike linked to a video game, designed for kids aged 10-18 with repaired congenital heart disease. Participants will do high intensity interval training three times a week for 12 weeks. The goal is to see if this fun, telemedicine-supported p…

This study uses special MRI scans to look at how the heart and muscles work together during exercise in children with heart disease or those who have had a heart transplant. Researchers want to learn more about what affects fitness in these kids. About 20 children aged 10 to 18 w…

This study is collecting movement data from 40 healthy children and young adults aged 3 to 25. Participants will walk while cameras and force plates record their motion. The goal is to create a baseline of normal movement patterns, which can help doctors better understand and tre…

This study looks at how children with leukemia process common medicines like painkillers, diuretics, and antibiotics. Researchers will measure drug levels in the blood to better understand dosing. The goal is to make these drugs safer and more effective for kids. No new treatment…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study looks at brain MRI scans and genetic information from 2000 children (healthy and with developmental delays) to create computer models that can predict developmental disorders. The goal is to find patterns in brain structure and genes that explain these conditions. No n…

This study is checking if pulse oximeters—the clip-on devices that measure oxygen levels—are equally accurate in children with different skin colors. Researchers will compare readings from the device to a precise blood test in 650 children undergoing heart procedures. The goal is…