Fish oil treatment tested for kids with liver damage from IV nutrition

NCT ID NCT06274788

Recruiting now Disease control Sponsor: Fresenius Kabi Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study is testing the safety of Omegaven, a fish oil-based fat emulsion, in 40 children under 18 who have developed liver problems (cholestasis) from long-term IV nutrition. The main goal is to see how many children develop essential fatty acid deficiency during at least 8 weeks of treatment. Researchers will also watch for symptoms like dry skin, hair loss, and poor growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Omegaven (fish oil triglycerides) injectable emulsion
What this could lead to: If successful, this could show that Omegaven is a safe way to provide essential fats and calories to children with liver problems caused by IV nutrition.
What could go wrong: This is a small, early-phase safety study with only 40 participants. It may not prove effectiveness, and some children might still develop fatty acid deficiency or other side effects.

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Conditions

The condition(s) this trial relates to.

childhood acute lymphoblastic leukemia intestinal failure–associated liver disease Malnutrition nutritional deficiency disease parenteral nutrition-associated cholestasis Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL FATTY ACID DEFICIENCY MALNUTRITION PARENTERAL NUTRITION ASSOCIATED LIVER DISEASE (PNALD) PEDIATRIC ALL

Contacts and locations

Locations

Baylor College of Medicine Houston
RECRUITING

Houston, Texas, 77030, United States
Board of Regents of the University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Children's Hospital Corporation d/b/a Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Memorial Health Service
RECRUITING

Fountain Valley, California, 92708, United States
Seattle Children's Hospital d/b/a Seattle Children's Research Institute
RECRUITING

Seattle, Washington, 98105, United States
The University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
The University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229-3901, United States
University of California Los Angeles
RECRUITING

Los Angeles, California, 10911, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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