Parenteral nutrition-associated cholestasis
MONDO:0035777A rare hepatic disease characterized by intrahepatic cholestasis and deterioration of liver function in patients receiving parenteral nutrition for extended periods of time (signs may appear as early as within the first two weeks of initiation of parenteral nutrition). The condition commonly occurs in neonates and usually resolves with transition to enteral feeding, although severe cases may progress to liver fibrosis, cirrhosis, and portal hypertension.
Also known as: PNAC
19 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New study checks if IV fat emulsion prevents nutrient shortages in Long-Term patients
Disease control Recruiting nowThis study looks at how safe SMOFlipid is for children and adults who need IV nutrition for 8 weeks or more. It checks if the treatment causes a lack of essential fats or liver problems. About 100 participants will be followed to see how their bodies respond.
Phase: PHASE4 • Sponsor: Fresenius Kabi • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Fish oil treatment tested for kids with liver damage from IV nutrition
Disease control Recruiting nowThis study is testing the safety of Omegaven, a fish oil-based fat emulsion, in 40 children under 18 who have developed liver problems (cholestasis) from long-term IV nutrition. The main goal is to see how many children develop essential fatty acid deficiency during at least 8 we…
Sponsor: Fresenius Kabi • Aim: Disease control
Last updated Jun 26, 2026 13:42 UTC
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New study aims to make bile duct drainage safer
Symptom relief Recruiting nowThis study tests two methods for widening a blocked bile duct during a special endoscopy procedure. One method uses a mechanical dilator, the other uses an electrocautery device. The goal is to see which causes less bleeding. The trial will involve 64 patients who cannot have sta…
Phase: NA • Sponsor: National Taiwan University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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NIH launches massive GI data bank to fuel future discoveries
Knowledge-focused Recruiting nowThis study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Gene hunt for mysterious adult liver disease
Knowledge-focused Recruiting nowThis study is using advanced whole-genome sequencing to find hidden genetic causes of cholestatic liver disease in adults whose condition remains unexplained after standard tests. Researchers will compare the DNA of 60 affected adults to a large group of healthy controls. The goa…
Phase: NA • Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Bile duct battle: which backup technique works best?
Knowledge-focused Recruiting nowThis study compares two advanced techniques used when doctors have trouble reaching the bile duct during a procedure called ERCP. About 188 adults with difficult bile duct access will be randomly assigned to either an endoscopic ultrasound-guided rendezvous technique or an early …
Phase: NA • Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Albumin recovery time may forecast surgical outcomes
Knowledge-focused Recruiting nowThis study tracks 1,000 patients undergoing major liver, pancreas, or bile duct surgery to see if the time it takes for their albumin levels to return to normal can predict complications and length of hospital stay. Albumin is a protein that drops after surgery due to inflammatio…
Sponsor: Institute of Liver and Biliary Sciences, India • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC