PEDIATRIC ALL

This study looks at whether Omegaven, a special fat emulsion given through an IV, is safe for children under 18 who have developed liver problems from long-term IV feeding. The main goal is to see how many children develop a lack of essential fatty acids, which can cause skin iss…

This early-stage study is testing a new type of immune cell therapy (CAR T-cells) for children and young adults up to age 21 whose leukemia has returned or not responded to standard treatments. The therapy uses donor immune cells that are specially trained to find and attack leuk…

This study looks at whether a special brain wave (EEG) score can predict if a child will need a higher dose of sedation medicine for a successful brain MRI. About 50 children under 5 (or older children at risk of moving) will receive a standard low dose of sedation, and doctors w…

This study tests a computer tool called pediatric eCART that uses information from electronic health records to quickly identify hospitalized children at risk of serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put i…

This study tests if a special exercise bike that connects to video games can help teenagers with congenital heart disease improve their fitness. About 44 teens aged 10 to 18 will use the bike at home for high-intensity interval training. The goal is to see if this fun, remote pro…

This study looks at which parts of therapy work best to help children aged 8-17 with post-traumatic stress disorder (PTSD) after a traumatic event. Researchers will compare different treatment components to a placebo to see what reduces symptoms most effectively. About 200 childr…

This study tests whether a home-based, video game-linked exercise bike (MedBIKE) can help 10 kids aged 10-18 who have had a heart transplant improve their fitness. Participants will do high-intensity interval training (short bursts of hard exercise with rest) for 12 weeks. The ma…

This study tests whether a drug called sugammadex can lower the chance of children becoming agitated after strabismus (crossed eyes) surgery. About 76 children aged 4 to 7 will receive either sugammadex or another drug (neostigmine) to reverse anesthesia. The goal is to see if su…

This study looks at whether pulse oximeters—the clip-on devices that measure oxygen levels—are equally accurate for children of all skin colors. Researchers will compare readings from the device with a precise blood test in 650 children undergoing heart catheterization. The goal …

This study follows 4,000 children who receive orthopedic implants (like rods, screws, or plates) for broken bones, limb deformities, or hip problems. Researchers will track how well the implants work, how long they last, and any side effects. The goal is to make sure these device…

This study aims to create a simple, accurate tool using sensors and machine learning to detect motor delays in infants as young as 1 month old. Researchers will observe 1,700 babies, including those with brain injuries and healthy controls, to see if automated assessments can pre…

This study watches how children under 21 with a type of leukemia called ALL process their usual medicines. Researchers will measure drug levels in the blood to learn more about dosing. No new drugs are tested; only standard treatments are observed. The goal is to improve future c…

This study follows about 40 people who received a Miltenyi CAR T cell therapy at least one year ago. Researchers will track side effects, overall health, and any return of cancer over the long term. The goal is to better understand the lasting safety and effects of this treatment…

This study looks at brain MRI scans and genetic information from up to 2000 children (healthy and with developmental delays) to create computer models that can better predict and explain developmental disorders. The goal is to learn more about how the brain grows and changes, not…

This study collects movement data from 40 healthy children and teens aged 3-25. Participants walk, run, and do other activities while cameras and force plates record their body positions and joint movements. The goal is to create a baseline of normal movement to compare with chil…

This study will use special MRI scans taken during exercise to learn how the heart and skeletal muscles work together in children with heart disease or who have had a heart transplant. Researchers want to understand why these children often have trouble being active. The study in…