Can a daily pill help shed excess weight? a new trial investigates
NCT ID NCT07770841
First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time
Summary
This Phase 3 trial is investigating whether lower doses of oral semaglutide can help adults with overweight or obesity lose weight. Participants will take either the medication or a placebo daily, and researchers will measure the percentage change in body weight. The goal is to find the most effective lower dose for weight management.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- semaglutide (taken orally)
- What this could lead to
- If successful, this could provide a convenient, lower-dose oral option for weight management in people with overweight or obesity.
- What could go wrong
- This is an early-stage trial, so results may not confirm effectiveness or safety. Side effects and individual variability could limit its impact.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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AIPSMC - DiMed EOOD
RECRUITINGHaskovo, 6300, Bulgaria
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Aarhus Universitetshospital, Steno Diabetes Center Aarhus
RECRUITINGAarhus N, 8200, Denmark
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Anima Research Center
RECRUITINGAlken, 3570, Belgium
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Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
RECRUITINGMarousi, 15125, Greece
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Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department
RECRUITINGPeristeri, 121 31, Greece
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Athleticomed Sp. z o.o.
NOT_YET_RECRUITINGBydgoszcz, 85-752, Poland
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CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques
NOT_YET_RECRUITINGVénissieux, 69200, France
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CTC GoCo Mölndal
RECRUITINGMölndal, 431 53, Sweden
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CTC Stockholm
RECRUITINGStockholm, 171 64, Sweden
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Care Access Polska Sp. Z o.o.
NOT_YET_RECRUITINGWarsaw, 00-719, Poland
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Cedar Health Research
NOT_YET_RECRUITINGDallas, Texas, 75251, United States
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Centro Periferico De Especialidades Bola Azul
NOT_YET_RECRUITINGAlmería, 04009, Spain
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Centrum Zdrowia Metabolicznego Paweł Bogdański
NOT_YET_RECRUITINGPoznan, 60-589, Poland
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City Hospital Kliniki Monoprosopi I.K.E.
NOT_YET_RECRUITINGKalamata, 24100, Greece
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Clínica Gaias Santiago
NOT_YET_RECRUITINGSantiago de Compostela, 15702, Spain
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Clínica Nuevas Tecnologías en Diabetes y Endocrinología
NOT_YET_RECRUITINGSeville, 41003, Spain
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Clínica Palacios Madrid
NOT_YET_RECRUITINGMadrid, 28009, Spain
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Corvallis Clinic PC Clinical Research Department
NOT_YET_RECRUITINGCorvallis, Oregon, 97330-3737, United States
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DCC 1 Velingrad EOOD
RECRUITINGVelingrad, 4600, Bulgaria
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DCC Neoklinik EAD
RECRUITINGSofia, 1408, Bulgaria
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ERG Holding Company, LLC / Evolution Research Group, LLC
NOT_YET_RECRUITINGDelray Beach, Florida, 33445, United States
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ERG Holding Company, LLC / Evolution Research Group, LLC
NOT_YET_RECRUITINGFort Myers, Florida, 33192, United States
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East West Med Res Inst
NOT_YET_RECRUITINGHonolulu, Hawaii, 96814, United States
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Enheten för Kliniska Studier (EKS), Örebro
RECRUITINGÖrebro, 701 85, Sweden
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FutureMeds Sp. z o.o.
NOT_YET_RECRUITINGWarsaw, 03-291, Poland
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Gentofte Hospital - Center for Klinisk Metabolisk Forskning
RECRUITINGHellerup, 2900, Denmark
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Gierach-Med
NOT_YET_RECRUITINGBygdoszcz, 85-796, Poland
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H. Infanta Luisa_Endocrino y Obesidad
NOT_YET_RECRUITINGSeville, 41010, Spain
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HU de Fuenlabrada_Endocrinología
NOT_YET_RECRUITINGFuenlabrada, Madrid, 28042, Spain
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Headlands Research California, LLC
NOT_YET_RECRUITINGEscondido, California, 92025, United States
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Hospital Naval Ferrol
NOT_YET_RECRUITINGFerrol, 15405, Spain
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Hospital Vithas Sevilla
NOT_YET_RECRUITINGCastilleja de la Cuesta, 41950, Spain
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Hôpital Privé La Louvière_Service de chirurgie
NOT_YET_RECRUITINGLille, 59800, France
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Hôpital Privé Saint Martin_Service de chirurgie digestive
NOT_YET_RECRUITINGCaen, 14000, France
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IPMC - Dr. Elizabeta Dimitrova
NOT_YET_RECRUITINGPetrich, 2850, Bulgaria
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Imelda
NOT_YET_RECRUITINGBonheiden, 2820, Belgium
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Jedidiah Clinical Research
NOT_YET_RECRUITINGTampa, Florida, 33619, United States
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Jubilee Clinical Research, Inc.
NOT_YET_RECRUITINGLas Vegas, Nevada, 89106, United States
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KORMONT
RECRUITINGKluisbergen, 9690, Belgium
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Kresmed Sp. z o. o.
NOT_YET_RECRUITINGBialystok, 15-481, Poland
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L-MARC Research Center
NOT_YET_RECRUITINGLouisville, Kentucky, 40213, United States
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LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service d'endocrinologie
NOT_YET_RECRUITINGLe Coudray, 28630, France
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Los Angeles Institute for Metabolic Research
NOT_YET_RECRUITINGLos Angeles, California, 90015, United States
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MHAT Hadzhi Dimitar OOD
RECRUITINGSliven, 8800, Bulgaria
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Medical Center Zdrave Lom EOOD
RECRUITINGLom, 3600, Bulgaria
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NBR Polska Tomasz Klodawski
NOT_YET_RECRUITINGWarsaw, 00-710, Poland
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National Research Institute - Huntington Park
NOT_YET_RECRUITINGHuntington Park, California, 90255, United States
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NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes
RECRUITINGThessaloniki, 54635, Greece
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Praktijk Dokters van Nederhoven
NOT_YET_RECRUITINGZwijndrecht, 3334 SB, Netherlands
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Progress Clinical Research Amsterdam
NOT_YET_RECRUITINGAmsterdam, 1081 GN, Netherlands
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Progress Clinical Research Zwolle
NOT_YET_RECRUITINGZwolle, 8025 AZ, Netherlands
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Regionshospitalet Gødstrup, Hjertesygdomme
RECRUITINGHerning, 7400, Denmark
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Santa Sp. z o.o.
NOT_YET_RECRUITINGLodz, 90-302, Poland
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Selma Medical Associates
NOT_YET_RECRUITINGWinchester, Virginia, 22601-3834, United States
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Spartanburg Medical Research
NOT_YET_RECRUITINGSpartanburg, South Carolina, 29303, United States
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StudyMetrix Research LLC
NOT_YET_RECRUITINGCity of Saint Peters, Missouri, 63303, United States
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Thermi Clinic S.A. - Diabetes and Internal Medicine Department
RECRUITINGThessaloniki, 57001, Greece
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UPA Ctr Weight and Eating Dis
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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UZ Brussel - Universitair Ziekenhuis Brussel
NOT_YET_RECRUITINGBrussels, 1090, Belgium
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Uni of Alabama at Birmingham
NOT_YET_RECRUITINGBirmingham, Alabama, 35296, United States
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Universitair Ziekenhuis Gent
RECRUITINGGhent, 9000, Belgium
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Velocity Nova Sp. z o.o.
NOT_YET_RECRUITINGStaszów, 28-200, Poland
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