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Personalized chemo dosing may boost leukemia remission in kids

NCT ID NCT06099366

Recruiting now ⭐️ CURE ⭐️ Sponsor: Hee Young Ju Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether using advanced genetic testing (NGS) to measure leftover cancer cells after initial treatment can help doctors tailor chemotherapy for children with standard-risk acute lymphoblastic leukemia. Around 116 children aged 1 to 10 will receive a standard chemotherapy regimen, but those with detectable cancer cells after induction may get more intensive treatment. The goal is to see if this personalized approach improves the five-year survival rate without relapse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a combination of chemotherapy drugs (vincristine, L-asparaginase, dexamethasone, methotrexate, cytarabine, cyclophosphamide, mercaptopurine) with doses guided by genetic testing
What this could lead to
If successful, this approach could increase the chance of long-term remission and reduce relapse in children with leukemia.
What could go wrong
This is a Phase 2 trial, so the approach is still being tested. Chemotherapy carries risks like infection, nerve damage, and organ toxicity.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia childhood acute lymphoblastic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOBLASTIC LEUKEMIA IN CHILDREN

Contacts and locations

Locations

  • Ajou University Medical Center

    RECRUITING

    Suwon, 16499, South Korea

  • Asan Medical Center

    RECRUITING

    Seoul, Other (Non U.s.), 03174, South Korea

  • Chonnam National University Hwasun Hospital

    NOT_YET_RECRUITING

    Hwasun, 58128, South Korea

  • Chungnam National University Hospital

    NOT_YET_RECRUITING

    Daejeon, 35015, South Korea

  • Jeju National University Hospital

    RECRUITING

    Jeju City, 63241, South Korea

  • Korea University Anam Hospital

    RECRUITING

    Seoul, 02841, South Korea

  • Kyungpook National University Chilgok-Hospital

    NOT_YET_RECRUITING

    Daegu, 41404, South Korea

  • Pusan National University Yangsan Hospital

    RECRUITING

    Yangsan, Yangsan-si, 50612, South Korea

  • Samsung Medical Center

    RECRUITING

    Seoul, Other (Non U.s.), 03174, South Korea

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam, 13620, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Seoul saint Mary's Hospital

    RECRUITING

    Seoul, 06591, South Korea

  • Severance Hospital

    RECRUITING

    Seoul, 03722, South Korea

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