Radioactive antibody plus immunotherapy shows promise in kidney cancer trial
NCT ID NCT05239533
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 study tests a combination of two drugs—nivolumab (an immunotherapy) and a radioactive antibody called 177Lu-girentuximab—in people with advanced clear cell kidney cancer that has the CAIX protein. The goal is to find the safest dose and see if the combination shrinks tumors. Only 9 participants are enrolled, so results are very early.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nivolumab combined with a radioactive antibody (177Lu-girentuximab)
What this could lead to
If successful, this combination could offer a new treatment option for people with advanced clear cell kidney cancer that has not responded to other therapies.
What could go wrong
This is a very early, small phase 2 trial with only 9 participants. The combination may cause significant side effects, and it is not yet known if it works better than existing treatments.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, 10065, United States
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Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (Limited Protocol Activites)
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)
Commack, New York, 11725, United States
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Memorial Sloan Kettering Westchester (Limited Protocol Activites)
Harrison, New York, 10604, United States