Heated chemotherapy showdown: which works better for abdominal cancer spread?

NCT ID NCT01815359

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways of giving chemotherapy directly into the belly after surgery to remove visible cancer from the lining of the abdomen. The cancer comes from the appendix, colon, or rectum. About 292 adults will be randomly assigned to receive either early post-operative chemotherapy (EPIC) or heated chemotherapy (HIPEC) during surgery. The goal is to see which approach helps people stay cancer-free longer and has fewer side effects.

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Conditions

The condition(s) this trial relates to.

appendiceal neoplasm appendix cancer colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APPENDIX CANCER COLORECTAL CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Consent and Follow up)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Consent and Follow up)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (Consent and Follow up)

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Consent and Follow up)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Consent and Follow up)

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester (Consent and Follow up)

Harrison, New York, 10604, United States
University of Miami

Miami, Florida, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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