New approach aims to shield patients from Chemo's toxic aftermath
NCT ID NCT03684980
Summary
This study is testing whether adding a drug called glucarpidase (Voraxaze) to the standard treatment for central nervous system lymphoma helps the body clear the chemotherapy drug methotrexate more quickly. The goal is to see if this faster clearance reduces potential side effects and toxicity from methotrexate, which can linger in the body. The trial involves adults with this type of brain or spinal cord lymphoma who are receiving standard treatment.
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Contacts and locations
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Locations
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cleveland Clinic (Data Collection and Specimen Collection)
Cleveland, Ohio, 44195, United States
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Dana Farber Cancer Institute (Data Collection and Specimen Analysis)
Boston, Massachusetts, 02115, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
Conditions
Explore the condition pages connected to this study.