Immune cells take on brain cancer in first human test

NCT ID NCT05651178

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase trial tests a new treatment for people with a rare and hard-to-treat type of lymphoma that has spread to the brain or spinal cord. The therapy uses the patient's own immune cells, modified to target two markers (CD19 and CD22) on cancer cells, and is given through a vein and directly into the spinal fluid. The main goals are to check safety and see if the treatment can shrink tumors, with 10 adults enrolled.

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Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia diffuse large B-cell lymphoma of the central nervous system lymphoma primary central nervous system lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006, China