Experimental pill plus chemo takes aim at Hard-to-Treat brain lymphoma
NCT ID NCT07608731
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a new oral drug called golcadomide combined with standard chemotherapy drugs (pemetrexed, rituximab, and dexamethasone) in 18 adults with large B-cell lymphoma that has spread to the brain or central nervous system and has either returned or is not responding to current treatment. The main goals are to check the safety of the combination and find the best dose. Participants will receive up to six 21-day cycles of treatment and be followed for about 2.5 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Golcadomide (an experimental drug taken orally) combined with pemetrexed, rituximab, and dexamethasone (standard chemotherapy drugs)
What this could lead to
If this works, it could point toward a new treatment option for people with CNS lymphoma that has come back or stopped responding to therapy.
What could go wrong
This is a very early Phase 1 trial with only 18 participants, so it is primarily testing safety and dosing—not yet proving effectiveness. The drug combination may cause side effects or fail to shrink tumors.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, Ohio, 44122, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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